Literature DB >> 17430120

Endothelium as a therapeutic target in sepsis.

William C Aird1.   

Abstract

The endothelium plays an important role in health and disease. Endothelial dysfunction contributes to sepsis pathophysiology. An important goal is to develop novel therapies that reverse endothelial dysfunction in sepsis. This review will consider the role of the endothelium in sepsis and will highlight its untapped therapeutic potential.

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Year:  2007        PMID： 17430120     DOI： 10.2174/138945007780362782

Source DB:  PubMed          Journal:  Curr Drug Targets        ISSN： 1389-4501            Impact factor:   3.465


  31 in total

Review 1.  Translational systems approaches to the biology of inflammation and healing.

Authors:  Yoram Vodovotz; Gregory Constantine; James Faeder; Qi Mi; Jonathan Rubin; John Bartels; Joydeep Sarkar; Robert H Squires; David O Okonkwo; Jörg Gerlach; Ruben Zamora; Shirley Luckhart; Bard Ermentrout; Gary An
Journal:  Immunopharmacol Immunotoxicol       Date:  2010-06       Impact factor: 2.730

2.  Risk of Acute Stroke After Hospitalization for Sepsis: A Case-Crossover Study.

Authors:  Amelia K Boehme; Purnima Ranawat; Jorge Luna; Hooman Kamel; Mitchell S V Elkind
Journal:  Stroke       Date:  2017-02-14       Impact factor: 7.914

3.  Collaborative Enhancement of Endothelial Targeting of Nanocarriers by Modulating Platelet-Endothelial Cell Adhesion Molecule-1/CD31 Epitope Engagement.

Authors:  Ann-Marie Chacko; Jingyan Han; Colin F Greineder; Blaine J Zern; John L Mikitsh; Madhura Nayak; Divya Menon; Ian H Johnston; Mortimer Poncz; David M Eckmann; Peter F Davies; Vladimir R Muzykantov
Journal:  ACS Nano       Date:  2015-07-13       Impact factor: 15.881

Review 4.  Breaking the wall: targeting of the endothelium by pathogenic bacteria.

Authors:  Emmanuel Lemichez; Marc Lecuit; Xavier Nassif; Sandrine Bourdoulous
Journal:  Nat Rev Microbiol       Date:  2009-12-30       Impact factor: 60.633

5.  Resveratrol Prevented Lipopolysaccharide-Induced Endothelial Dysfunction in Rat Thoracic Aorta Through Increased eNOS Expression.

Authors:  Seda Sultan Uğurel; Nilay Kuşçu; Çiler Çelik Özenci; Selvinaz Dalaklıoğlu; Arda Taşatargil
Journal:  Balkan Med J       Date:  2016-03-01       Impact factor: 2.021

6.  MicroRNA-181b regulates NF-κB-mediated vascular inflammation.

Authors:  Xinghui Sun; Basak Icli; Akm Khyrul Wara; Nathan Belkin; Shaolin He; Lester Kobzik; Gary M Hunninghake; Miguel Pinilla Vera; Timothy S Blackwell; Rebecca M Baron; Mark W Feinberg
Journal:  J Clin Invest       Date:  2012-05-24       Impact factor: 14.808

7.  The effects of microRNA-34a regulating Notch-1/NF-κB signaling pathway on lipopolysaccharide-induced human umbilical vein endothelial cells.

Authors:  Yun Ge; Man Huang; Yue-Feng Ma
Journal:  World J Emerg Med       Date:  2017

8.  Acid Sphingomyelinase Promotes Endothelial Stress Response in Systemic Inflammation and Sepsis.

Authors:  Ha-Yeun Chung; Daniel C Hupe; Gordon P Otto; Marcel Sprenger; Alexander C Bunck; Michael J Dorer; Clemens L Bockmeyer; Hans-Peter Deigner; Markus H Gräler; Ralf A Claus
Journal:  Mol Med       Date:  2016-06-15       Impact factor: 6.354

9.  Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation.

Authors:  Rajesh Kumar Gandhirajan; Shu Meng; Harish C Chandramoorthy; Karthik Mallilankaraman; Salvatore Mancarella; Hui Gao; Roshanak Razmpour; Xiao-Feng Yang; Steven R Houser; Ju Chen; Walter J Koch; Hong Wang; Jonathan Soboloff; Donald L Gill; Muniswamy Madesh
Journal:  J Clin Invest       Date:  2013-01-25       Impact factor: 14.808

10.  Sepsis-associated microvascular dysfunction measured by peripheral arterial tonometry: an observational study.

Authors:  Joshua S Davis; Tsin W Yeo; Jane H Thomas; Mark McMillan; Christabelle J Darcy; Yvette R McNeil; Allen C Cheng; David S Celermajer; Dianne P Stephens; Nicholas M Anstey
Journal:  Crit Care       Date:  2009-09-25       Impact factor: 9.097
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