Literature DB >> 17428563

Family-based association study between GRIK2 polymorphisms and autism spectrum disorders in the Korean trios.

Soon Ae Kim1, Jin Hee Kim, Mira Park, In Hee Cho, Hee Jeong Yoo.   

Abstract

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with strong genetic components. The present study comprises the detection of four single nucleotide polymorphisms (SNPs) in GRIK2 followed by a family-based association analysis of the SNPs in 126 Korean ASD trios by using the transmission disequilibrium test (TDT) and haplotype analysis. We found preferential transmission of the C allele at the rs3213607 (P<0.001) of GRIK2 in ASD and haplotype analysis revealed that one haplotype demonstrated a significant association (P=0.023). These results suggest a potential association between GRIK2 and ASD in the Korean population.

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Year:  2007        PMID： 17428563     DOI： 10.1016/j.neures.2007.03.002

Source DB:  PubMed          Journal:  Neurosci Res        ISSN： 0168-0102            Impact factor:   3.304


  21 in total

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