STUDY OBJECTIVE: The aim was to examine whether mid-systolic deceleration of the pulmonary flow wave occurred in acute pulmonary hypertension due to pulmonary artery constriction and pulmonary embolisation, and if so whether it was related to reflection. DESIGN: Various degrees of pulmonary hypertension were induced by both pulmonary artery constriction and pulmonary embolisation in dogs. During control periods and during pulmonary artery constriction and pulmonary embolisation, pulmonary flow and pulmonary artery pressure were recorded, and the forward and backward (reflected) flow waves were separated from the measured pulmonary flow wave by the method of Westerhof et al. MATERIALS: 20 adult mongrel dogs were used and 10 dogs qualified for analysis. The other 10 dogs, which died before both interventions were completed, were excluded. MEASUREMENTS AND MAIN RESULTS: During pulmonary artery constriction, a distinct mid-systolic deceleration of the pulmonary flow wave was observed in five of the 10 dogs, while during pulmonary embolisation, no mid-systolic deceleration was found in these five dogs. The distinct deceleration of the pulmonary flow wave was related to a steep fall and early negative peak in the backward flow wave. CONCLUSION: Mid-systolic deceleration of pulmonary flow wave is likely to be related to reflection.
STUDY OBJECTIVE: The aim was to examine whether mid-systolic deceleration of the pulmonary flow wave occurred in acute pulmonary hypertension due to pulmonary artery constriction and pulmonary embolisation, and if so whether it was related to reflection. DESIGN: Various degrees of pulmonary hypertension were induced by both pulmonary artery constriction and pulmonary embolisation in dogs. During control periods and during pulmonary artery constriction and pulmonary embolisation, pulmonary flow and pulmonary artery pressure were recorded, and the forward and backward (reflected) flow waves were separated from the measured pulmonary flow wave by the method of Westerhof et al. MATERIALS: 20 adult mongrel dogs were used and 10 dogs qualified for analysis. The other 10 dogs, which died before both interventions were completed, were excluded. MEASUREMENTS AND MAIN RESULTS: During pulmonary artery constriction, a distinct mid-systolic deceleration of the pulmonary flow wave was observed in five of the 10 dogs, while during pulmonary embolisation, no mid-systolic deceleration was found in these five dogs. The distinct deceleration of the pulmonary flow wave was related to a steep fall and early negative peak in the backward flow wave. CONCLUSION: Mid-systolic deceleration of pulmonary flow wave is likely to be related to reflection.
Authors: G B Bleeker; P Steendijk; E R Holman; C-M Yu; O A Breithardt; T A M Kaandorp; M J Schalij; E E van der Wall; J J Bax; P Nihoyannopoulos Journal: Heart Date: 2006-04 Impact factor: 5.994
Authors: Robert V MacKenzie Ross; Mark R Toshner; Elaine Soon; Robert Naeije; Joanna Pepke-Zaba Journal: Am J Physiol Heart Circ Physiol Date: 2013-05-17 Impact factor: 4.733
Authors: Andreas Rolf; Johannes Rixe; Won K Kim; Stefan Guth; Nils Körlings; Helge Möllmann; Holger M Nef; Christoph Liebetrau; Gabriele Krombach; Thorsten Kramm; Eckhard Mayer; Christian W Hamm Journal: Int J Cardiovasc Imaging Date: 2014-12-18 Impact factor: 2.357
Authors: Manuel J Richter; Steven Hsu; Athiththan Yogeswaran; Faeq Husain-Syed; István Vadász; Hossein A Ghofrani; Robert Naeije; Sebastian Harth; Friedrich Grimminger; Werner Seeger; Henning Gall; Ryan J Tedford; Khodr Tello Journal: Am J Physiol Lung Cell Mol Physiol Date: 2021-03-03 Impact factor: 5.464