| Literature DB >> 17425919 |
Shi Fang Yan1, Gaetano R Barile, Vivette D'Agati, Shi Du Yan, Ravichandran Ramasamy, Ann Marie Schmidt.
Abstract
The interaction of glucose-modified and inflammation-promoting ligands with the receptor for advanced glycation end products (RAGE) is emerging as a central mechanism contributing to the diverse complications of diabetes. These ligands, particularly in oligomeric form, bind to RAGE and transduce intracellular signals. The consequences of this interaction, as elucidated in cultured cells and animal models, include upregulation of inflammatory and tissue-degradative pathways. Pharmacologic antagonism of RAGE may hold promise for the treatment of diabetic complications.Entities:
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Year: 2007 PMID： 17425919 DOI： 10.1007/s11892-007-0024-4
Source DB: PubMed Journal: Curr Diab Rep ISSN： 1534-4827 Impact factor: 5.430