Literature DB >> 17425492

What is the best adjuvant treatment for very young patients with medulloblastoma?

James W Clarke1, Mersiha Hadziahmetovic, Katherine Tzou, Ching C Lau, Arnold C Paulino, John C Grecula, Joseph F Montebello, Nina A Mayr, Simon S Lo.   

Abstract

The standard treatment for medulloblastoma is surgery followed by adjuvant chemotherapy and external beam radiotherapy to the craniospinal axis and posterior fossa. However, in very young children, craniospinal irradiation has a more significant detrimental effect in terms of neurocognitive function and growth. This article reviews the different strategies used for very young patients with medulloblastoma.

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Year:  2007        PMID： 17425492     DOI： 10.1586/14737175.7.4.373

Source DB:  PubMed          Journal:  Expert Rev Neurother        ISSN： 1473-7175            Impact factor:   4.618


  2 in total

1.  Treatment of early childhood medulloblastoma by postoperative chemotherapy and deferred radiotherapy.

Authors:  Stefan Rutkowski; Nicolas Ulrich Gerber; Katja von Hoff; Astrid Gnekow; Udo Bode; Norbert Graf; Frank Berthold; Günter Henze; Johannes E A Wolff; Monika Warmuth-Metz; Niels Soerensen; Angela Emser; Holger Ottensmeier; Frank Deinlein; Paul-Gerhardt Schlegel; Rolf-Dieter Kortmann; Torsten Pietsch; Joachim Kuehl
Journal:  Neuro Oncol       Date:  2008-09-25       Impact factor: 12.300

2.  Induction chemotherapy and conformal radiation therapy for very young children with nonmetastatic medulloblastoma: Children's Oncology Group study P9934.

Authors:  David M Ashley; Thomas E Merchant; Douglas Strother; Tianni Zhou; Patricia Duffner; Peter C Burger; Douglas C Miller; Nancy Lyon; Melanie J Bonner; Michael Msall; Allen Buxton; Russell Geyer; Larry E Kun; Lee Coleman; Ian F Pollack
Journal:  J Clin Oncol       Date:  2012-07-30       Impact factor: 44.544
  2 in total

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