Gastrinoma (Zollinger-Ellison Syndrome) in the Dog and cat.

Tumors of gastrin-secreting cells (gastrinomas) result in a characteristic clinical syndrome of hypergastrinemia, which leads to gastric acid hypersecretion with subsequent severe gastrointestinal ulceration. The most common clinical signs are inappetance/anorexia, lethargy, weight loss, vomiting, diarrhea, and hypoalbuminemia. Hypergastrinemia is also seen in other disorders and caution should be used in utilizing fasting serum gastrin concentrations as the sole diagnostic criterion.