Bioavailability of chloramphenicol in cattle: variation with the number of injection sites and the concentration of the pharmaceutical preparation.

A bioavailability study of three commercial chloramphenicol preparations was carried out in cattle in order to determine the influence of the number of muscular injection sites and the concentration of the product on the level of chloramphenicol serum concentration. Results show that chloramphenicol should be injected at the dose of 22 mg/kg at multiple injection sites to reach 5 mug/mL of serum which is considered to be the minimal inhibitory concentration.