Literature DB >> 1742028

Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB.

L R Berkemeier1, J W Winslow, D R Kaplan, K Nikolics, D V Goeddel, A Rosenthal.   

Abstract

In vertebrates, the formation and maintenance of neuronal connections are subject to regulation by multiple target-derived, diffusible (neurotrophic) factors. Here we describe the identification and characterization of a novel neurotrophic factor designated neurotrophin-5 (NT-5). NT-5 is structurally related to nerve growth factor and is expressed in embryonic as well as adult tissues. Recombinant NT-5 promotes the survival of peripheral sensory and sympathetic neurons and induces differentiation of the pheochromocytoma cell line PC12. NT-5 activates two trk-related tyrosine kinase receptors and shares these receptors with other neurotrophins. Activation of multiple receptors may permit a single neurotrophin to control target innervation by distinct neuronal populations. Receptor sharing could enable neurotrophic factors emanating from distinct targets to cooperate in regulating neurons with multiple connections.

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Year:  1991        PMID： 1742028     DOI： 10.1016/0896-6273(91)90287-a

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  114 in total

Review 1.  Peripheral nerve regeneration and neurotrophic factors.

Authors:  G Terenghi
Journal:  J Anat       Date:  1999-01       Impact factor: 2.610

2.  Predominant neuronal B-cell loss in L5 DRG of p75 receptor-deficient mice.

Authors:  M Dreetz Gjerstad; T Tandrup; M Koltzenburg; J Jakobsen
Journal:  J Anat       Date:  2002-01       Impact factor: 2.610

Review 3.  Regulation of neurotrophin signaling in aging sensory and motoneurons: dissipation of target support?

Authors:  B Ulfhake; E Bergman; E Edstrom; B T Fundin; H Johnson; S Kullberg; Y Ming
Journal:  Mol Neurobiol       Date:  2000-06       Impact factor: 5.590

4.  Brain-derived neurotrophic factor rapidly enhances phosphorylation of the postsynaptic N-methyl-D-aspartate receptor subunit 1.

Authors:  P C Suen; K Wu; E S Levine; H T Mount; J L Xu; S Y Lin; I B Black
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-22       Impact factor: 11.205

Review 5.  Neuronal cell cultures: a tool for investigations in developmental neurobiology.

Authors:  A Cestelli; G Savettieri; G Salemi; I Di Liegro
Journal:  Neurochem Res       Date:  1992-12       Impact factor: 3.996

6.  Nerve growth factor induces cell cycle arrest of astrocytes.

Authors:  Andrea B Cragnolini; Marta Volosin; Yangyang Huang; Wilma J Friedman
Journal:  Dev Neurobiol       Date:  2012-06       Impact factor: 3.964

7.  Upregulation of BDNF mRNA expression in the barrel cortex of adult mice after sensory stimulation.

Authors:  N Rocamora; E Welker; M Pascual; E Soriano
Journal:  J Neurosci       Date:  1996-07-15       Impact factor: 6.167

8.  Neurotrophin 4 is required for the survival of a subclass of hair follicle receptors.

Authors:  C L Stucky; T DeChiara; R M Lindsay; G D Yancopoulos; M Koltzenburg
Journal:  J Neurosci       Date:  1998-09-01       Impact factor: 6.167

9.  Neurotrophin 3 rescues neuronal precursors from apoptosis and promotes neuronal differentiation in the embryonic metanephric kidney.

Authors:  A Karavanov; K Sainio; J Palgi; M Saarma; L Saxen; H Sariola
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-21       Impact factor: 11.205

10.  SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells.

Authors:  S J Rabin; V Cleghon; D R Kaplan
Journal:  Mol Cell Biol       Date:  1993-04       Impact factor: 4.272
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