| Literature DB >> 17419985 |
Renata Basto1, Jonathon Pines.
Abstract
During mitosis, the interaction between chromosomes and microtubules requires nuclear envelope disassembly in prophase. Two articles in this issue of Developmental Cell show that centrosomes have a role in promoting nuclear envelope breakdown (Hachet et al., 2007; Portier et al., 2007). Surprisingly, the role of the centrosome in this process is independent of its role as a microtubule nucleation organelle. Instead, the centrosome seems to act as a spatial regulator for the activation of the Aurora A kinase.Mesh：
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Year: 2007 PMID： 17419985 DOI： 10.1016/j.devcel.2007.03.012
Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270