Literature DB >> 17418695

Lifelong ethanol consumption and brain regional GABAA receptor subunit mRNA expression in alcohol-preferring rats.

Maija Sarviharju1, Petri Hyytiä, Antti Hervonen, Pia Jaatinen, Kalervo Kiianmaa, Esa R Korpi.   

Abstract

Brain regional gamma-aminobutyric acid type A (GABAA) receptor subunit mRNA expression was studied in ethanol-preferring AA (Alko, Alcohol) rats after moderate ethanol drinking for up to 2 years of age. In situ hybridization with oligonucleotide probes specific for 13 different subunits was used with coronal cryostat sections of the brains. Selective alterations were observed by ethanol exposure and/or aging in signals for several subunits. Most interestingly, the putative highly ethanol-sensitive alpha4 and beta3 subunit mRNAs were significantly decreased in several brain regions. The age-related alterations in alpha4 subunit expression were parallel to those caused by lifelong ethanol drinking, whereas aging had no significant effect on beta3 subunit expression. The results suggest that prolonged ethanol consumption leading to blood concentrations of about 10 mM may downregulate the mRNA expression of selected GABAA receptor subunits and that aging might have partly similar effects.

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Year:  2007        PMID： 17418695     DOI： 10.1016/j.alcohol.2006.11.003

Source DB:  PubMed          Journal:  Alcohol        ISSN： 0741-8329            Impact factor:   2.405


  8 in total

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7.  Effects of Lifelong Ethanol Consumption on Brain Monoamine Transmitters in Alcohol-Preferring Alko Alcohol (AA) Rats.

Authors:  Pia Jaatinen; Maija Sarviharju; Noora Raivio; C J Peter Eriksson; Antti Hervonen; Kalervo Kiianmaa
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  8 in total

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