Literature DB >> 17418684

Regulation of transforming growth factor beta in diabetic nephropathy: implications for treatment.

Yanqing Zhu1, Hitomi Kataoka Usui, Kumar Sharma.   

Abstract

The recognition that the drivers of matrix accumulation is an appropriate therapeutic target for diabetic nephropathy is now accepted by the nephrology and pharmaceutical communities. Interventions focused around transforming growth factor-beta (TGF-beta) likely will be an important area of clinical investigation in the near future. Understanding the various pathways involved in stimulating TGF-beta in the diabetic kidney is of paramount importance in devising strategies to combat the development and progression of diabetic nephropathy. In this review we highlight the major pathways involved in stimulating TGF-beta production by increased glucose levels and discuss the therapeutic implications thereof.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17418684      PMCID： PMC1948024          DOI： 10.1016/j.semnephrol.2007.01.008

Source DB:  PubMed          Journal:  Semin Nephrol        ISSN： 0270-9295            Impact factor:   5.299


  88 in total

1.  Negative regulation of transforming growth factor-beta by the proteoglycan decorin.

Authors:  Y Yamaguchi; D M Mann; E Ruoslahti
Journal:  Nature       Date:  1990-07-19       Impact factor: 49.962

2.  P38 mitogen-activated protein kinase mediates hexosamine-induced TGFbeta1 mRNA expression in human mesangial cells.

Authors:  D J Burt; G Gruden; S M Thomas; P Tutt; C Dell'Anna; G C Viberti; L Gnudi
Journal:  Diabetologia       Date:  2003-04-05       Impact factor: 10.122

3.  Intercellular adhesion molecule-1-deficient mice are resistant against renal injury after induction of diabetes.

Authors:  Shinichi Okada; Kenichi Shikata; Mitsuhiro Matsuda; Daisuke Ogawa; Hitomi Usui; Yuichi Kido; Ryo Nagase; Jun Wada; Yasushi Shikata; Hirofumi Makino
Journal:  Diabetes       Date:  2003-10       Impact factor: 9.461

4.  Diminished loss of proteoglycans and lack of albuminuria in protein kinase C-alpha-deficient diabetic mice.

Authors:  Jan Menne; Joon-Keun Park; Martin Boehne; Marlies Elger; Carsten Lindschau; Torsten Kirsch; Matthias Meier; Faikah Gueler; Annette Fiebeler; Ferdinand H Bahlmann; Michael Leitges; Hermann Haller
Journal:  Diabetes       Date:  2004-08       Impact factor: 9.461

5.  Hyaluronan structures synthesized by rat mesangial cells in response to hyperglycemia induce monocyte adhesion.

Authors:  Aimin Wang; Vincent C Hascall
Journal:  J Biol Chem       Date:  2003-12-16       Impact factor: 5.157

6.  Upstream stimulatory factor (USF) proteins induce human TGF-beta1 gene activation via the glucose-response element-1013/-1002 in mesangial cells: up-regulation of USF activity by the hexosamine biosynthetic pathway.

Authors:  Cora Weigert; Katrin Brodbeck; Michèle Sawadogo; Hans U Häring; Erwin D Schleicher
Journal:  J Biol Chem       Date:  2004-02-02       Impact factor: 5.157

7.  Increased expression of thrombospondin-1 in vessel wall of diabetic Zucker rat.

Authors:  Olga I Stenina; Irene Krukovets; Kai Wang; Zhongmin Zhou; Farhad Forudi; Marc S Penn; Eric J Topol; Edward F Plow
Journal:  Circulation       Date:  2003-06-16       Impact factor: 29.690

8.  Add-on anti-TGF-beta antibody to ACE inhibitor arrests progressive diabetic nephropathy in the rat.

Authors:  Ariela Benigni; Carla Zoja; Daniela Corna; Cristina Zatelli; Sara Conti; Marco Campana; Elena Gagliardini; Daniela Rottoli; Cristina Zanchi; Mauro Abbate; Steve Ledbetter; Giuseppe Remuzzi
Journal:  J Am Soc Nephrol       Date:  2003-07       Impact factor: 10.121

9.  High glucose-suppressed endothelin-1 Ca2+ signaling via NADPH oxidase and diacylglycerol-sensitive protein kinase C isozymes in mesangial cells.

Authors:  Hong Hua; Snezana Munk; Howard Goldberg; I George Fantus; Catharine I Whiteside
Journal:  J Biol Chem       Date:  2003-06-23       Impact factor: 5.157

10.  Attenuation of renal injury in db/db mice overexpressing superoxide dismutase: evidence for reduced superoxide-nitric oxide interaction.

Authors:  Frederick R DeRubertis; Patricia A Craven; Mona F Melhem; Eman M Salah
Journal:  Diabetes       Date:  2004-03       Impact factor: 9.461
View more
  44 in total

Review 1.  Sodium-glucose transport: role in diabetes mellitus and potential clinical implications.

Authors:  Volker Vallon; Kumar Sharma
Journal:  Curr Opin Nephrol Hypertens       Date:  2010-09       Impact factor: 2.894

Review 2.  Nuclear receptors in renal disease.

Authors:  Moshe Levi
Journal:  Biochim Biophys Acta       Date:  2011-04-14

Review 3.  Nuclear hormone receptors in diabetic nephropathy.

Authors:  Xiaoxin X Wang; Tao Jiang; Moshe Levi
Journal:  Nat Rev Nephrol       Date:  2010-04-27       Impact factor: 28.314

4.  Deletion of soluble epoxide hydrolase gene improves renal endothelial function and reduces renal inflammation and injury in streptozotocin-induced type 1 diabetes.

Authors:  Ahmed A Elmarakby; Jessica Faulkner; Mohammed Al-Shabrawey; Mong-Heng Wang; Krishna Rao Maddipati; John D Imig
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2011-08-10       Impact factor: 3.619

Review 5.  MicroRNAs in diabetic nephropathy: functions, biomarkers, and therapeutic targets.

Authors:  Mitsuo Kato; Rama Natarajan
Journal:  Ann N Y Acad Sci       Date:  2015-04-15       Impact factor: 5.691

6.  FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity.

Authors:  Xiaoxin X Wang; Dong Wang; Yuhuan Luo; Komuraiah Myakala; Evgenia Dobrinskikh; Avi Z Rosenberg; Jonathan Levi; Jeffrey B Kopp; Amanda Field; Ashley Hill; Scott Lucia; Liru Qiu; Tao Jiang; Yingqiong Peng; David Orlicky; Gabriel Garcia; Michal Herman-Edelstein; Vivette D'Agati; Kammi Henriksen; Luciano Adorini; Mark Pruzanski; Cen Xie; Kristopher W Krausz; Frank J Gonzalez; Suman Ranjit; Alexander Dvornikov; Enrico Gratton; Moshe Levi
Journal:  J Am Soc Nephrol       Date:  2017-10-31       Impact factor: 10.121

7.  SGLT2 Protein Expression Is Increased in Human Diabetic Nephropathy: SGLT2 PROTEIN INHIBITION DECREASES RENAL LIPID ACCUMULATION, INFLAMMATION, AND THE DEVELOPMENT OF NEPHROPATHY IN DIABETIC MICE.

Authors:  Xiaoxin X Wang; Jonathan Levi; Yuhuan Luo; Komuraiah Myakala; Michal Herman-Edelstein; Liru Qiu; Dong Wang; Yingqiong Peng; Almut Grenz; Scott Lucia; Evgenia Dobrinskikh; Vivette D D'Agati; Hermann Koepsell; Jeffrey B Kopp; Avi Z Rosenberg; Moshe Levi
Journal:  J Biol Chem       Date:  2017-02-14       Impact factor: 5.157

8.  Shuttling of calcium between endoplasmic reticulum and mitochondria in the renal vasculature.

Authors:  Yashpal S Kanwar; Lin Sun
Journal:  Am J Physiol Renal Physiol       Date:  2008-09-03

Review 9.  Can we target tubular damage to prevent renal function decline in diabetes?

Authors:  Joseph V Bonventre
Journal:  Semin Nephrol       Date:  2012-09       Impact factor: 5.299

Review 10.  Targeting pericyte differentiation as a strategy to modulate kidney fibrosis in diabetic nephropathy.

Authors:  Benjamin D Humphreys
Journal:  Semin Nephrol       Date:  2012-09       Impact factor: 5.299
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.