BACKGROUND: Small cell lung carcinoma (SCLC) is frequently associated with a paraneoplastic syndrome. CASE REPORT: We report on a rare case of SCLC presenting with syndrome of inappropriate antidiuretic hormone (SIADH) secretion and ectopic ACTH production. In accordance with the endocrine evaluation, immunohistochemical staining of the tumour was positive for ADH and ACTH. Chemotherapy with etoposide and carboplatin induced a nearly complete remission. CONCLUSION: Simultaneous secretion of ADH and ACTH is infrequently reported with only five cases described in the literature. SIADH in patients with ectopic ACTH syndrome may be underdiagnosed due to the antagonistic hormone actions of cortisol and ADH on renal sodium excretion.
BACKGROUND:Small cell lung carcinoma (SCLC) is frequently associated with a paraneoplastic syndrome. CASE REPORT: We report on a rare case of SCLC presenting with syndrome of inappropriate antidiuretic hormone (SIADH) secretion and ectopic ACTH production. In accordance with the endocrine evaluation, immunohistochemical staining of the tumour was positive for ADH and ACTH. Chemotherapy with etoposide and carboplatin induced a nearly complete remission. CONCLUSION: Simultaneous secretion of ADH and ACTH is infrequently reported with only five cases described in the literature. SIADH in patients with ectopic ACTH syndrome may be underdiagnosed due to the antagonistic hormone actions of cortisol and ADH on renal sodium excretion.
Authors: Aya Kosuda; Toru Shirahata; Nasa Kudo; Yuki Uehara; Masayoshi Miyawaki; Aika Hagiwara; Rie Murakami; Ken Shimizu Journal: Intern Med Date: 2019-09-11 Impact factor: 1.271
Authors: Andrea Casadei Gardini; Marita Mariotti; Alessandro Lucchesi; Sara Pini; Martina Valgiusti; Sara Bravaccini; Angelo Del Monte; Marco Angelo Burgio; Giorgia Marisi; Dino Amadori; Giovanni Luca Frassineti Journal: BMC Cancer Date: 2016-02-17 Impact factor: 4.430