| Literature DB >> 17418141 |
Päivi Ramu1, Rauna Tanskanen, Mikko Holmberg, Kaarina Lähteenmäki, Timo K Korhonen, Seppo Meri.
Abstract
Complement activity in mammalian serum is fundamentally based on three homologous components C3b, C4b and C5. During systemic infection, the gastrointestinal pathogen Salmonella enterica disseminates within host phagocytic cells but also extracellularly. Consequently, systemic Salmonella transiently confronts the complement system. We show here that the surface protease PgtE of S. enterica proteolytically cleaves C3b, C4b and C5 and that the expression of PgtE enhances bacterial resistance to human serum. Degradation of C3b was further enhanced by PgtE-mediated plasminogen activation.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17418141 DOI： 10.1016/j.febslet.2007.03.049
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124