Literature DB >> 17418068

Asthma treatment in a population-based cohort: putting step-up and step-down treatment changes in context.

Barbara P Yawn1, Peter C Wollan, Susan L Bertram, David Lowe, Joseph H Butterfield, Denise Bonde, James T C Li.   

Abstract

OBJECTIVE: To assess the frequency and types of visits related to modifications in the intensity of asthma medications. PATIENTS AND METHODS: We retrospectively reviewed the medical records of adults (aged 18-40 years) and children (aged 6-17 years) living in Olmsted County, Minnesota, to evaluate changes in asthma medications by dose and drug class and site and type of visit (routine vs unscheduled) at the time of changes. All records from all visits were reviewed for each patient to identify asthma-related visits at all sites of care from January 1, 2002, through December 31, 2003.
RESULTS: The study consisted of 397 adults and children. In 255 patients, 597 asthma medication changes occurred. Step-up changes usually occurred because of an exacerbation or loss of control of asthma and adhered to the medication hierarchy in the national asthma guidelines. Twenty step-up changes involved skipping inhaled corticosteroid (ICS) monotherapy and moving directly to combined ICSs plus a long-acting beta-agonist (LABA). Lack of documentation of asthma symptom frequency or interference with activities made it impossible to determine whether these 'skips' were appropriate. Only 78 physician-directed step-down changes were documented, usually to a lower dose of combined ICSs and LABAs or a move from combined ICSs and LABAs to anti-inflammatory monotherapy. Patients initiated additional step-down changes between encounters. Step-down changes occurred at routine or follow-up asthma visits, but the limited number of such visits provided few opportunities for step-down care.
CONCLUSION: The continuing episodic-style treatment of asthma aimed at exacerbation management facilitates step-up changes in asthma therapy. The dearth of asthma evaluation visits limited opportunities to step down use of asthma medications and to provide long-term asthma management.

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Year:  2007        PMID: 17418068     DOI: 10.4065/82.4.414

Source DB:  PubMed          Journal:  Mayo Clin Proc        ISSN: 0025-6196            Impact factor:   7.616


  8 in total

1.  Trigger recognition and management in poorly controlled asthmatics.

Authors:  Matthew A Rank; Peter Wollan; James T Li; Barbara P Yawn
Journal:  Allergy Asthma Proc       Date:  2010-10-25       Impact factor: 2.587

2.  Toward the optimal control of asthma.

Authors:  James T C Li
Journal:  Mayo Clin Proc       Date:  2009-08       Impact factor: 7.616

Review 3.  Assessing the risks and benefits of step-down asthma care: a case-based approach.

Authors:  John B Hagan; Matthew A Rank
Journal:  Curr Allergy Asthma Rep       Date:  2015-04       Impact factor: 4.806

4.  Use of Asthma APGAR Tools in Primary Care Practices: A Cluster-Randomized Controlled Trial.

Authors:  Barbara P Yawn; Peter C Wollan; Matthew A Rank; Susan L Bertram; Young Juhn; Wilson Pace
Journal:  Ann Fam Med       Date:  2018-03       Impact factor: 5.166

5.  Introduction of Asthma APGAR tools improve asthma management in primary care practices.

Authors:  Barbara P Yawn; Susan Bertram; Peter Wollan
Journal:  J Asthma Allergy       Date:  2008-08-31

6.  Asthma exacerbations and traffic: examining relationships using link-based traffic metrics and a comprehensive patient database.

Authors:  Paula Lindgren; Jean Johnson; Allan Williams; Barbara Yawn; Gregory C Pratt
Journal:  Environ Health       Date:  2016-11-03       Impact factor: 5.984

Review 7.  How to step down asthma preventer treatment in patients with well-controlled asthma - more is not always better.

Authors:  Helen K Reddel; Gloria J Foxley; Sharon R Davis
Journal:  Aust Prescr       Date:  2022-08-01

8.  Health and cost impact of stepping down asthma medication for UK patients, 2001-2017: A population-based observational study.

Authors:  Chloe I Bloom; Laure de Preux; Aziz Sheikh; Jennifer K Quint
Journal:  PLoS Med       Date:  2020-07-21       Impact factor: 11.069

  8 in total

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