INTRODUCTION: Breast conservation therapy (BCT) increases quality of life and self-esteem of breast cancer patients. In special cancer centers up to 90% of patients are treated with BCT. T3/T4 breast cancer is one of the few contraindications for BCT. However, retrospective data suggest that BCT may be eligible in selected cases of T3/T4 breast cancer. METHOD: We analyzed retrospectively 196 breast cancer patients (operated between 1995 and 2004) suffering from T3/T4 tumors and compared BCT and radiotherapy with mastectomy in these patients in terms of overall survival (OS), local recurrence free-survival (LRFS) and breast cancer-related death (BCRD). RESULT: Demographic data showed no significant differences in prognostic factors between patients treated with mastectomy compared with BCT. Kaplan-Meier curves demonstrated no significant difference for OS, LRFS and BCRD between the two groups. DISCUSSION: Our data strongly suggest that BCT with R0 resection followed by radiotherapy is feasible in patients with T3/T4 breast cancer. Prospective studies have to be performed to further investigate this issue.
INTRODUCTION: Breast conservation therapy (BCT) increases quality of life and self-esteem of breast cancerpatients. In special cancer centers up to 90% of patients are treated with BCT. T3/T4 breast cancer is one of the few contraindications for BCT. However, retrospective data suggest that BCT may be eligible in selected cases of T3/T4 breast cancer. METHOD: We analyzed retrospectively 196 breast cancerpatients (operated between 1995 and 2004) suffering from T3/T4 tumors and compared BCT and radiotherapy with mastectomy in these patients in terms of overall survival (OS), local recurrence free-survival (LRFS) and breast cancer-related death (BCRD). RESULT: Demographic data showed no significant differences in prognostic factors between patients treated with mastectomy compared with BCT. Kaplan-Meier curves demonstrated no significant difference for OS, LRFS and BCRD between the two groups. DISCUSSION: Our data strongly suggest that BCT with R0 resection followed by radiotherapy is feasible in patients with T3/T4 breast cancer. Prospective studies have to be performed to further investigate this issue.
Authors: Marieke E M van der Noordaa; Ileana Ioan; Emiel J Rutgers; Erik van Werkhoven; Claudette E Loo; Rosie Voorthuis; Jelle Wesseling; Japke van Urk; Terry Wiersma; Vincent Dezentje; Marie-Jeanne T F D Vrancken Peeters; Frederieke H van Duijnhoven Journal: Ann Surg Oncol Date: 2021-05-12 Impact factor: 5.344
Authors: Richard J Bleicher; Karen Ruth; Elin R Sigurdson; John M Daly; Marcia Boraas; Penny R Anderson; Brian L Egleston Journal: Cancer Date: 2015-10-19 Impact factor: 6.860
Authors: Thomas Kolben; Susanne Beyer; Sanaz Ghasemi; Kerstin Hermelink; Sarah Meister; Tom Degenhardt; Isabelle Himsl; Franz Edler von Koch; Theresa M Kolben; Rachel Wuerstlein; Sven Mahner; Nadia Harbeck; Anna Hester Journal: Breast Care (Basel) Date: 2020-09-21 Impact factor: 2.268
Authors: Anna M Mazor; Alina M Mateo; Lyudmila Demora; Elin R Sigurdson; Elizabeth Handorf; John M Daly; Allison A Aggon; Penny R Anderson; Stephanie E Weiss; Richard J Bleicher Journal: Breast Cancer Res Treat Date: 2018-10-20 Impact factor: 4.872
Authors: Mary Kathryn Abel; Case E Brabham; Ruby Guo; Kelly Fahrner-Scott; Jasmine Wong; Michael Alvarado; Cheryl Ewing; Laura J Esserman; Rita A Mukhtar Journal: Am J Surg Date: 2020-06-19 Impact factor: 2.565
Authors: G Thomas; T-Q Nguyen; I J Pence; B Caldwell; M E O'Connor; J Giltnane; M E Sanders; A Grau; I Meszoely; M Hooks; M C Kelley; A Mahadevan-Jansen Journal: Sci Rep Date: 2017-10-19 Impact factor: 4.379