Literature DB >> 17417633

CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock.

Jason P DeBruyne1, David R Weaver, Steven M Reppert.   

Abstract

Heterodimers of CLOCK and BMAL1, bHLH-PAS transcription factors, are believed to be the major transcriptional regulators of the circadian clock mechanism in mammals. However, a recent study shows that CLOCK-deficient mice continue to exhibit robust behavioral and molecular rhythms. Here we report that the transcription factor NPAS2 (MOP4) is able to functionally substitute for CLOCK in the master brain clock in mice to regulate circadian rhythmicity.

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Year:  2007        PMID： 17417633      PMCID： PMC2782643          DOI： 10.1038/nn1884

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  13 in total

1.  Impaired cued and contextual memory in NPAS2-deficient mice.

Authors:  J A Garcia; D Zhang; S J Estill; C Michnoff; J Rutter; M Reick; K Scott; R Diaz-Arrastia; S L McKnight
Journal:  Science       Date:  2000-06-23       Impact factor: 47.728

Review 2.  Coordination of circadian timing in mammals.

Authors:  Steven M Reppert; David R Weaver
Journal:  Nature       Date:  2002-08-29       Impact factor: 49.962

3.  Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice.

Authors:  Carol A Dudley; Claudia Erbel-Sieler; Sandi Jo Estill; Martin Reick; Paul Franken; SiNae Pitts; Steven L McKnight
Journal:  Science       Date:  2003-07-03       Impact factor: 47.728

4.  NPAS2: an analog of clock operative in the mammalian forebrain.

Authors:  M Reick; J A Garcia; C Dudley; S L McKnight
Journal:  Science       Date:  2001-07-05       Impact factor: 47.728

5.  Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors.

Authors:  J Rutter; M Reick; L C Wu; S L McKnight
Journal:  Science       Date:  2001-07-05       Impact factor: 47.728

6.  Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system.

Authors:  Y D Zhou; M Barnard; H Tian; X Li; H Z Ring; U Francke; J Shelton; J Richardson; D W Russell; S L McKnight
Journal:  Proc Natl Acad Sci U S A       Date:  1997-01-21       Impact factor: 11.205

7.  A clock shock: mouse CLOCK is not required for circadian oscillator function.

Authors:  Jason P Debruyne; Elizabeth Noton; Christopher M Lambert; Elizabeth S Maywood; David R Weaver; Steven M Reppert
Journal:  Neuron       Date:  2006-05-04       Impact factor: 17.173

8.  Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway.

Authors:  J B Hogenesch; W K Chan; V H Jackiw; R C Brown; Y Z Gu; M Pray-Grant; G H Perdew; C A Bradfield
Journal:  J Biol Chem       Date:  1997-03-28       Impact factor: 5.157

9.  Mop3 is an essential component of the master circadian pacemaker in mammals.

Authors:  M K Bunger; L D Wilsbacher; S M Moran; C Clendenin; L A Radcliffe; J B Hogenesch; M C Simon; J S Takahashi; C A Bradfield
Journal:  Cell       Date:  2000-12-22       Impact factor: 41.582

Review 10.  Mammalian circadian biology: elucidating genome-wide levels of temporal organization.

Authors:  Phillip L Lowrey; Joseph S Takahashi
Journal:  Annu Rev Genomics Hum Genet       Date:  2004       Impact factor: 8.929
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  183 in total

1.  Coordination of the transcriptome and metabolome by the circadian clock.

Authors:  Kristin L Eckel-Mahan; Vishal R Patel; Robert P Mohney; Katie S Vignola; Pierre Baldi; Paolo Sassone-Corsi
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-19       Impact factor: 11.205

Review 2.  Clocks not winding down: unravelling circadian networks.

Authors:  Eric E Zhang; Steve A Kay
Journal:  Nat Rev Mol Cell Biol       Date:  2010-11       Impact factor: 94.444

3.  Stoichiometric relationship among clock proteins determines robustness of circadian rhythms.

Authors:  Yongjin Lee; Rongmin Chen; Hyeong-min Lee; Choogon Lee
Journal:  J Biol Chem       Date:  2011-01-03       Impact factor: 5.157

Review 4.  Circadian rhythms and mood regulation: insights from pre-clinical models.

Authors:  Colleen A McClung
Journal:  Eur Neuropsychopharmacol       Date:  2011-08-11       Impact factor: 4.600

5.  Ecstasy (MDMA) Alters Cardiac Gene Expression and DNA Methylation: Implications for Circadian Rhythm Dysfunction in the Heart.

Authors:  Christopher A Koczor; Ivan Ludlow; Robert S Hight; Zhe Jiao; Earl Fields; Tomika Ludaway; Rodney Russ; Rebecca A Torres; William Lewis
Journal:  Toxicol Sci       Date:  2015-08-06       Impact factor: 4.849

6.  Cell-Type-Specific Regulation of Nucleus Accumbens Synaptic Plasticity and Cocaine Reward Sensitivity by the Circadian Protein, NPAS2.

Authors:  Puja K Parekh; Ryan W Logan; Kyle D Ketchesin; Darius Becker-Krail; Micah A Shelton; Mariah A Hildebrand; Kelly Barko; Yanhua H Huang; Colleen A McClung
Journal:  J Neurosci       Date:  2019-04-08       Impact factor: 6.167

Review 7.  The Retinal Circadian Clock and Photoreceptor Viability.

Authors:  Kenkichi Baba; Christophe P Ribelayga; P Michael Iuvone; Gianluca Tosini
Journal:  Adv Exp Med Biol       Date:  2018       Impact factor: 2.622

8.  Circadian rhythm of contrast sensitivity is regulated by a dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling pathway in retinal ganglion cells.

Authors:  Christopher K Hwang; Shyam S Chaurasia; Chad R Jackson; Guy C-K Chan; Daniel R Storm; P Michael Iuvone
Journal:  J Neurosci       Date:  2013-09-18       Impact factor: 6.167

Review 9.  Oscillating perceptions: the ups and downs of the CLOCK protein in the mouse circadian system.

Authors:  Jason P Debruyne
Journal:  J Genet       Date:  2008-12       Impact factor: 1.166

10.  The circadian gene NPAS2, a putative tumor suppressor, is involved in DNA damage response.

Authors:  Aaron E Hoffman; Tongzhang Zheng; Yue Ba; Yong Zhu
Journal:  Mol Cancer Res       Date:  2008-09       Impact factor: 5.852
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