Literature DB >> 17416669

Interspecies DNA microarray analysis identifies WblA as a pleiotropic down-regulator of antibiotic biosynthesis in Streptomyces.

Seung-Hoon Kang1, Jianqiang Huang, Han-Na Lee, Yoon-Ah Hur, Stanley N Cohen, Eung-Soo Kim.   

Abstract

Using Streptomyces coelicolor microarrays to discover regulators of gene expression in other Streptomyces species, we identified wblA, a whiB-like gene encoding a putative transcription factor, as a down-regulator of doxorubicin biosynthesis in Streptomyces peucetius. Further analysis revealed that wblA functions pleiotropically to control antibiotic production and morphological differentiation in streptomycetes. Our results reveal a novel biological role for wblA and show the utility of interspecies microarray analysis for the investigation of streptomycete gene expression.

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Year:  2007        PMID： 17416669      PMCID： PMC1913423          DOI： 10.1128/JB.01789-06

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  15 in total

1.  Multiple paralogous genes related to the Streptomyces coelicolor developmental regulatory gene whiB are present in Streptomyces and other actinomycetes.

Authors:  J A Soliveri; J Gomez; W R Bishai; K F Chater
Journal:  Microbiology       Date:  2000-02       Impact factor: 2.777

2.  Evidence that the Streptomyces developmental protein WhiD, a member of the WhiB family, binds a [4Fe-4S] cluster.

Authors:  Piotr Jakimowicz; Myles R Cheesman; William R Bishai; Keith F Chater; Andrew J Thomson; Mark J Buttner
Journal:  J Biol Chem       Date:  2004-12-21       Impact factor: 5.157

3.  Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius.

Authors:  K J Stutzman-Engwall; S L Otten; C R Hutchinson
Journal:  J Bacteriol       Date:  1992-01       Impact factor: 3.490

4.  Activation of the OxyR transcription factor by reversible disulfide bond formation.

Authors:  M Zheng; F Aslund; G Storz
Journal:  Science       Date:  1998-03-13       Impact factor: 47.728

Review 5.  Comparative aspects of development and differentiation in actinomycetes.

Authors:  L V Kalakoutskii; N S Agre
Journal:  Bacteriol Rev       Date:  1976-06

6.  Cross-regulation among disparate antibiotic biosynthetic pathways of Streptomyces coelicolor.

Authors:  Jianqiang Huang; Jing Shi; Virginie Molle; Björn Sohlberg; David Weaver; Maureen J Bibb; Nitsara Karoonuthaisiri; Chih-Jian Lih; Camilla M Kao; Mark J Buttner; Stanley N Cohen
Journal:  Mol Microbiol       Date:  2005-12       Impact factor: 3.501

7.  Reverse engineering of industrial pharmaceutical-producing actinomycete strains using DNA microarrays.

Authors:  Amy M Lum; Jianqiang Huang; C Richard Hutchinson; Camilla M Kao
Journal:  Metab Eng       Date:  2004-07       Impact factor: 9.783

Review 8.  Genetic regulation of secondary metabolic pathways in Streptomyces.

Authors:  K F Chater
Journal:  Ciba Found Symp       Date:  1992

9.  Solid-phase extraction and optimized separation of doxorubicin, epirubicin and their metabolites using reversed-phase high-performance liquid chromatography.

Authors:  G Nicholls; B J Clark; J E Brown
Journal:  J Pharm Biomed Anal       Date:  1992 Oct-Dec       Impact factor: 3.935

10.  Regulation of daunorubicin production in Streptomyces peucetius by the dnrR2 locus.

Authors:  S L Otten; J Ferguson; C R Hutchinson
Journal:  J Bacteriol       Date:  1995-03       Impact factor: 3.490
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  36 in total

1.  An orphan histidine kinase, OhkA, regulates both secondary metabolism and morphological differentiation in Streptomyces coelicolor.

Authors:  Yinhua Lu; Juanmei He; Hong Zhu; Zhenyu Yu; Rui Wang; Yunliang Chen; Fujun Dang; Weiwen Zhang; Sheng Yang; Weihong Jiang
Journal:  J Bacteriol       Date:  2011-04-22       Impact factor: 3.490

2.  Reverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis.

Authors:  Ying Zhuo; Wenquan Zhang; Difei Chen; Hong Gao; Jun Tao; Mei Liu; Zhongxuan Gou; Xianlong Zhou; Bang-Ce Ye; Qing Zhang; Siliang Zhang; Li-Xin Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-07       Impact factor: 11.205

Review 3.  Regulatory genes and their roles for improvement of antibiotic biosynthesis in Streptomyces.

Authors:  Fengjuan Lu; Yanyan Hou; Heming Zhang; Yiwen Chu; Haiyang Xia; Yongqiang Tian
Journal:  3 Biotech       Date:  2017-07-17       Impact factor: 2.406

Review 4.  Biosynthesis, regulation, and engineering of a linear polyketide tautomycetin: a novel immunosuppressant in Streptomyces sp. CK4412.

Authors:  Si-Sun Choi; Hee-Ju Nah; Hye-Rim Pyeon; Eung-Soo Kim
Journal:  J Ind Microbiol Biotechnol       Date:  2016-10-12       Impact factor: 3.346

5.  Large-Scale Transposition Mutagenesis of Streptomyces coelicolor Identifies Hundreds of Genes Influencing Antibiotic Biosynthesis.

Authors:  Zhong Xu; Yemin Wang; Keith F Chater; Hong-Yu Ou; H Howard Xu; Zixin Deng; Meifeng Tao
Journal:  Appl Environ Microbiol       Date:  2017-03-02       Impact factor: 4.792

6.  WblAch, a pivotal activator of natamycin biosynthesis and morphological differentiation in Streptomyces chattanoogensis L10, is positively regulated by AdpAch.

Authors:  Pin Yu; Shui-Ping Liu; Qing-Ting Bu; Zhen-Xing Zhou; Zhen-Hong Zhu; Fang-Liang Huang; Yong-Quan Li
Journal:  Appl Environ Microbiol       Date:  2014-08-29       Impact factor: 4.792

7.  Characterization of [4Fe-4S]-containing and cluster-free forms of Streptomyces WhiD.

Authors:  Jason C Crack; Chris D den Hengst; Piotr Jakimowicz; Sowmya Subramanian; Michael K Johnson; Mark J Buttner; Andrew J Thomson; Nick E Le Brun
Journal:  Biochemistry       Date:  2009-12-29       Impact factor: 3.162

Review 8.  Molecular regulation of antibiotic biosynthesis in streptomyces.

Authors:  Gang Liu; Keith F Chater; Govind Chandra; Guoqing Niu; Huarong Tan
Journal:  Microbiol Mol Biol Rev       Date:  2013-03       Impact factor: 11.056

9.  Identification of a cyclosporine-specific P450 hydroxylase gene through targeted cytochrome P450 complement (CYPome) disruption in Sebekia benihana.

Authors:  Mi-Jin Lee; Hyun-Bum Kim; Yeo Joon Yoon; Kyuboem Han; Eung-Soo Kim
Journal:  Appl Environ Microbiol       Date:  2013-01-25       Impact factor: 4.792

10.  Functional expression of SCO7832 stimulates tautomycetin production via pathway-specific regulatory gene overexpression in Streptomyces sp. CK4412.

Authors:  Shin-Hae Park; Si-Sun Choi; Yoon Jung Kim; Yong Keun Chang; David H Sherman; Eung-Soo Kim
Journal:  J Ind Microbiol Biotechnol       Date:  2009-05-01       Impact factor: 3.346
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