| Literature DB >> 17416526 |
Eric Alix1, Anne-Béatrice Blanc-Potard.
Abstract
Several bacterial pathogens have evolved strategies to survive in macrophages and create a replicative niche within phagosomes. The bacterial factor MgtC is a key player in intramacrophage survival, being important for virulence in diverse intracellular pathogens. MgtC is also required for growth under magnesium limitation. Recent studies provide new clues on the role of MgtC in macrophages, which seems to be unlinked to adaptation to a low Mg(2+) microenvironment. In addition, we discuss the unexpected finding that MgtC modulates host P-type ATPase activity.Entities:
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Year: 2007 PMID： 17416526 DOI： 10.1016/j.tim.2007.03.007
Source DB: PubMed Journal: Trends Microbiol ISSN： 0966-842X Impact factor: 17.079