BACKGROUND: National guidelines suggest that, with appropriate care, most patients can control their asthma. The probabilities of children achieving and maintaining control with ongoing care are unknown. OBJECTIVE: We sought to evaluate the degree to which children in a lower socioeconomic urban setting achieve and maintain control of asthma with regular participation in a disease management program that provides guideline-based care. METHODS: Interdisciplinary teams of asthma specialists use mobile clinics to offer ongoing care at schools and county clinics. A guideline-derived construct of asthma control is recorded at each visit. RESULTS: Two thousand one hundred eighty-five enrollees were eligible to evaluate the time to first achieve control, and 1591 patients were eligible to evaluate subsequent control maintenance. Depending on severity, 70% to 87% of patients with persistent asthma achieved control by visit 3, and 89% to 98% achieved control by visit 6. Subsequent control maintenance was highly variable. Thirty-nine percent of patients displayed well-controlled asthma (control at >90% of subsequent visits), whereas 13% displayed difficult-to-control asthma (<50% of subsequent visits). Patients from each baseline severity category were found in each group. Maintenance of control was influenced by physician-estimated compliance with the treatment plan, baseline severity, and the interval between clinic visits. CONCLUSIONS: Many children can achieve asthma control with regular visit intervals and guideline-based care; however, long-term control can be highly variable among patients in all severity categories. CLINICAL IMPLICATIONS: These findings highlight the need and feasibility for systematically tracking each patient's clinical response to individualize therapy and guide the use of population management strategies.
BACKGROUND: National guidelines suggest that, with appropriate care, most patients can control their asthma. The probabilities of children achieving and maintaining control with ongoing care are unknown. OBJECTIVE: We sought to evaluate the degree to which children in a lower socioeconomic urban setting achieve and maintain control of asthma with regular participation in a disease management program that provides guideline-based care. METHODS: Interdisciplinary teams of asthma specialists use mobile clinics to offer ongoing care at schools and county clinics. A guideline-derived construct of asthma control is recorded at each visit. RESULTS: Two thousand one hundred eighty-five enrollees were eligible to evaluate the time to first achieve control, and 1591 patients were eligible to evaluate subsequent control maintenance. Depending on severity, 70% to 87% of patients with persistent asthma achieved control by visit 3, and 89% to 98% achieved control by visit 6. Subsequent control maintenance was highly variable. Thirty-nine percent of patients displayed well-controlled asthma (control at >90% of subsequent visits), whereas 13% displayed difficult-to-control asthma (<50% of subsequent visits). Patients from each baseline severity category were found in each group. Maintenance of control was influenced by physician-estimated compliance with the treatment plan, baseline severity, and the interval between clinic visits. CONCLUSIONS: Many children can achieve asthma control with regular visit intervals and guideline-based care; however, long-term control can be highly variable among patients in all severity categories. CLINICAL IMPLICATIONS: These findings highlight the need and feasibility for systematically tracking each patient's clinical response to individualize therapy and guide the use of population management strategies.
Authors: Stanley J Szefler; Herman Mitchell; Christine A Sorkness; Peter J Gergen; George T O'Connor; Wayne J Morgan; Meyer Kattan; Jacqueline A Pongracic; Stephen J Teach; Gordon R Bloomberg; Peyton A Eggleston; Rebecca S Gruchalla; Carolyn M Kercsmar; Andrew H Liu; Jeremy J Wildfire; Matthew D Curry; William W Busse Journal: Lancet Date: 2008-09-20 Impact factor: 79.321
Authors: Jeremy J Wildfire; Peter J Gergen; Christine A Sorkness; Herman E Mitchell; Agustin Calatroni; Meyer Kattan; Stanley J Szefler; Stephen J Teach; Gordon R Bloomberg; Robert A Wood; Andrew H Liu; Jacqueline A Pongracic; James F Chmiel; Kathleen Conroy; Yadira Rivera-Sanchez; William W Busse; Wayne J Morgan Journal: J Allergy Clin Immunol Date: 2012-01-12 Impact factor: 10.793
Authors: Michelle N Eakin; Cynthia S Rand; Andrew Bilderback; Mary E Bollinger; Arlene Butz; Veni Kandasamy; Kristin A Riekert Journal: J Allergy Clin Immunol Date: 2011-11-21 Impact factor: 10.793
Authors: Jerry A Krishnan; Bruce G Bender; Frederick S Wamboldt; Stanley J Szefler; N Franklin Adkinson; Robert S Zeiger; Robert A Wise; Andrew L Bilderback; Cynthia S Rand Journal: J Allergy Clin Immunol Date: 2011-11-21 Impact factor: 10.793
Authors: Robert C Strunk; Leonard B Bacharier; Brenda R Phillips; Stanley J Szefler; Robert S Zeiger; Vernon M Chinchilli; Fernando D Martinez; Robert F Lemanske; Lynn M Taussig; David T Mauger; Wayne J Morgan; Christine A Sorkness; Ian M Paul; Theresa Guilbert; Marzena Krawiec; Ronina Covar; Gary Larsen Journal: J Allergy Clin Immunol Date: 2008-10-25 Impact factor: 10.793
Authors: Gordon R Bloomberg; Christina Banister; Randall Sterkel; Jay Epstein; Julie Bruns; Lisa Swerczek; Suzanne Wells; Yan Yan; Jane M Garbutt Journal: Pediatrics Date: 2009-03 Impact factor: 7.124