| Literature DB >> 17416344 |
Kensuke Koyama1, Tetsuro Ozawa, Kyosuke Hatsushika, Takashi Ando, Shinichi Takano, Masanori Wako, Fumiko Suenaga, Yuko Ohnuma, Tetsuro Ohba, Ryohei Katoh, Hajime Sugiyama, Yoshiki Hamada, Hideoki Ogawa, Ko Okumura, Atsuhito Nakao.
Abstract
Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine that triggers dendritic cell-mediated Th2-type inflammatory responses and is considered as a master switch for allergic inflammation. In this study, we found increased levels of TSLP and, also TNF-alpha as previously reported, in synovial fluid specimens derived from patients with rheumatoid arthritis (RA) when compared with those from patients with osteoarthritis (OA). In addition, TNF-alpha up-regulated TSLP expression in RA- and OA-derived synovial fibroblasts, which was inhibited by IFN-gamma. Furthermore, anti-TSLP neutralizing antibody ameliorated a TNF-alpha-dependent experimental arthritis induced by anti-type II collagen antibody in mice. Collectively, these results suggest that TSLP, as a downstream molecule of TNF-alpha, may be involved in the pathophysiology of inflammatory arthritis. TSLP might thus play a role not only in allergic diseases but also in inflammatory arthritis such as RA.Entities:
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Year: 2007 PMID： 17416344 DOI： 10.1016/j.bbrc.2007.03.081
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575