BACKGROUND: Oxidative stress has an important role in the pathogenesis of doxorubicin-induced hepatotoxicity. The aim of this study was to investigate the hepatoprotective effects of erdosteine, an antioxidant agent, on doxorubicin-induced hepatotoxicity. METHODS: Rats were divided into control, doxorubicin alone (20 mg/kg, i.p.) and doxorubicin plus erdosteine (50 mg/kg/day, oral) groups. At the end of the 10(th) day, liver tissues were removed for light microscopy and analysis. The levels of tissue protein carbonyl content, malondialdehyde and nitric oxide, as well as the activities of superoxide dismutase, catalase, were determined. RESULTS: The tissue of the doxorubicin group showed some histopathological changes such as necrosis, hepatocyte degeneration, sinusoidal dilatation, hemorrhage and vascular congestion and dilatation. In the doxorubicin plus erdosteine group, histopathological evidence of hepatic damage was markedly reduced. Biochemical parameters were consistent with histological parameters. CONCLUSIONS: Doxorubicin caused hepatotoxicity, and erdosteine treatment prevented lipid peroxidation and protein oxidant in liver tissue.
BACKGROUND: Oxidative stress has an important role in the pathogenesis of doxorubicin-induced hepatotoxicity. The aim of this study was to investigate the hepatoprotective effects of erdosteine, an antioxidant agent, on doxorubicin-induced hepatotoxicity. METHODS:Rats were divided into control, doxorubicin alone (20 mg/kg, i.p.) and doxorubicin plus erdosteine (50 mg/kg/day, oral) groups. At the end of the 10(th) day, liver tissues were removed for light microscopy and analysis. The levels of tissue protein carbonyl content, malondialdehyde and nitric oxide, as well as the activities of superoxide dismutase, catalase, were determined. RESULTS: The tissue of the doxorubicin group showed some histopathological changes such as necrosis, hepatocyte degeneration, sinusoidal dilatation, hemorrhage and vascular congestion and dilatation. In the doxorubicin plus erdosteine group, histopathological evidence of hepatic damage was markedly reduced. Biochemical parameters were consistent with histological parameters. CONCLUSIONS:Doxorubicin caused hepatotoxicity, and erdosteine treatment prevented lipid peroxidation and protein oxidant in liver tissue.
Authors: Ercan Gündüz; Recep Dursun; Yılmaz Zengin; Mustafa İçer; Hasan Mansur Durgun; Ayşe Kanıcı; İbrahim Kaplan; Ulaş Alabalık; Hüseyin Gürbüz; Cahfer Güloğlu Journal: Int J Clin Exp Med Date: 2015-05-15
Authors: Benjamin L Barthel; Zhiyong Zhang; Daniel L Rudnicki; Christopher D Coldren; Margaret Polinkovsky; Hengrui Sun; Gary G Koch; Daniel C F Chan; Tad H Koch Journal: J Med Chem Date: 2009-12-10 Impact factor: 7.446
Authors: Othman A Alshabanah; Mohamed M Hafez; Mohamed M Al-Harbi; Zeinab K Hassan; Salim S Al Rejaie; Yosef A Asiri; Mohamed M Sayed-Ahmed Journal: Oxid Med Cell Longev Date: 2010-11-01 Impact factor: 6.543
Authors: Salem S Al-Rejaie; Abdulaziz M Aleisa; Mohamed M Sayed-Ahmed; Othman A Al-Shabanah; Hatem M Abuohashish; Mohammed M Ahmed; Khaled A Al-Hosaini; Mohamed M Hafez Journal: BMC Complement Altern Med Date: 2013-06-17 Impact factor: 3.659