Literature DB >> 17416192

A simple HPLC-UV method for the determination of dimenhydrinate and related substances--dentification of an unknown impurity.

U Döge1, K Eger.   

Abstract

During the revision of the dimenhydrinate monograph of the European Pharmacopoeia a HPLC-UV method was developed. The procedure described allows a qualitative and quantitative determination of both dimenhydrinate compounds and of thirteen related substances. Furthermore a hitherto unknown impurity was identified and integrated into the purity check. Also 18 samples of dimenhydrinate have been tested. Thereby the relevant impurities of dimenhydrinate could be nominated and quantified.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17416192

Source DB:  PubMed          Journal:  Pharmazie        ISSN： 0031-7144            Impact factor:   1.267


  3 in total

1.  Experimentally designed chromatographic method for the simultaneous analysis of dimenhydrinate, cinnarizine and their toxic impurities.

Authors:  Fadwa H Edrees; Ahmed S Saad; Mohammed T Alsaadi; Noha H Amin; Nada S Abdelwahab
Journal:  RSC Adv       Date:  2021-01-05       Impact factor: 3.361

2.  Simultaneous estimation of dimenhydrinate, cinnarizine and their toxic impurities benzophenone and diphenylmethylpiperazine; in silico toxicity profiling of impurities.

Authors:  Nada S Abdelwahab; Fadwa H Edrees; Mohammed T Alsaadi; Noha H Amin; Ahmed S Saad
Journal:  RSC Adv       Date:  2020-10-09       Impact factor: 4.036

3.  Selective determination of dimenhydrinate in presence of six of its related substances and potential impurities using a direct GC/MS method.

Authors:  Tarek S Belal; Karim M Abdel-Hay; C Randall Clark
Journal:  J Adv Res       Date:  2015-02-07       Impact factor: 10.479
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.