Literature DB >> 17415880

Inhibitory activities of lichen-derived compounds against methicillin- and multidrug-resistant Staphylococcus aureus.

Tetsuo Kokubun1, Winnie Ka Po Shiu, Simon Gibbons.   

Abstract

The inhibitory effects of selected phenolic lichen substances were tested against a panel of methicillin- and multidrug-resistant Staphylococcus aureus. Depsidones with long alkyl chains on both of the aromatic rings were consistently active against the strains tested, comparable to or better than the level of clinically used antibacterial drugs. A similar level of activity was also observed for rhizocarpic acid. The previously described cytotoxic pentacyclic compound hybocarpone was by far the most active, exhibiting minimum inhibitory concentrations (MICs) of 4-8 microg/mL (8.13-16.3 microM) against a range of multidrug efflux pump expressing strains of S. aureus.

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Year:  2007        PMID： 17415880     DOI： 10.1055/s-2006-957070

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  6 in total

1.  Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target.

Authors:  Ina L Lauinger; Livia Vivas; Remo Perozzo; Christopher Stairiker; Alice Tarun; Mire Zloh; Xujie Zhang; Hua Xu; Peter J Tonge; Scott G Franzblau; Duc-Hung Pham; Camila V Esguerra; Alexander D Crawford; Louis Maes; Deniz Tasdemir
Journal:  J Nat Prod       Date:  2013-06-19       Impact factor: 4.050

2.  Depsidones inhibit aromatase activity and tumor cell proliferation in a co-culture of human primary breast adipose fibroblasts and T47D breast tumor cells.

Authors:  Suthat Chottanapund; M B M Van Duursen; Anne Zwartsen; Supatchaya Timtavorn; Panida Navasumrit; Prasat Kittakoop; Sanya Sureram; Mathuros Ruchirawat; Martin Van den Berg
Journal:  Toxicol Rep       Date:  2017-03-19

3.  Phytochemical Analysis, Cytotoxic, Antioxidant, and Antibacterial Activities of Lichens.

Authors:  Noura Aoussar; Fatima Ezzahra Laasri; Mohammed Bourhia; Nedeljko Manoljovic; Rajaa Ait Mhand; Naima Rhallabi; Riaz Ullah; Abdelaaty A Shahat; Omar M Noman; Fahd A Nasr; Omer M Almarfadi; Mohammed El Mzibri; Perica Vasiljević; Laila Benbacer; Fouad Mellouki
Journal:  Evid Based Complement Alternat Med       Date:  2020-12-02       Impact factor: 2.629

4.  Evaluation of Antimicrobial Properties of Lichen Substances against Plant Pathogens.

Authors:  Jaycee A Paguirigan; Rundong Liu; Seong Mi Im; Jae-Seoun Hur; Wonyong Kim
Journal:  Plant Pathol J       Date:  2022-02-01       Impact factor: 1.795

5.  Chemical Composition and Antimicrobial Activity of Two Sri Lankan Lichens, Parmotrema rampoddense, and Parmotrema tinctorum against Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus.

Authors:  Polwatta Samaraweera Arachchige Ishara Shiromi; Ruwani Punyakanthi Hewawasam; Rankoth Gedara Udeni Jayalal; Hasanga Rathnayake; Weerasinghe Mudiyanselage Dilip Gaya Bandara Wijayaratne; Dakshika Wanniarachchi
Journal:  Evid Based Complement Alternat Med       Date:  2021-06-01       Impact factor: 2.629

6.  Evaluation of anti-tumour properties of two depsidones - Unguinol and Aspergillusidone D - in triple-negative MDA-MB-231 breast tumour cells.

Authors:  A Zwartsen; S Chottanapund; P Kittakoop; P Navasumrit; M Ruchirawat; M B M Van Duursen; M Van den Berg
Journal:  Toxicol Rep       Date:  2019-10-20
  6 in total

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