CONTEXT: Incidence of insulin resistance (IR) in Americans is steadily rising. IR may be ameliorated with < or = 5% loss in body weight. OBJECTIVE: To examine effects of 2 weight-loss diets on body weight and composition in overweight adults with IR. DESIGN: Participants randomly assigned to a high-protein, low-fat (HPLF) or a high-carbohydrate, low-fat (HCLF) diet for 8 weeks. SETTING: All meals prepared and weighed in the metabolic kitchen at Arizona State University. Lunch consumed on-site; all other meals packaged for home consumption. PATIENTS: Twenty overweight, healthy participants with elevated fasting serum insulin (> or = 15 microU/L) were recruited. INTERVENTIONS: Both diets were low-fat (27% kcal from fat; < 7% saturated, < or = 10% monounsaturated, and < or = 10% polyunsaturated) and energy-restricted (energy levels were 1200, 1500, 1700 or 2000 kcal); HPLF: 32% protein, 41% carbohydrate; HCLF: 59% carbohydrate, 14% protein. Energy levels were assigned on the basis of participant's resting metabolic rate. MAIN OUTCOME MEASURES: Body composition, etabolic indices, fasting plasma glucose, and insulin. RESULTS: No significant differences were found in the main outcome measures between the diets. Body weight (HPLF: -4.9 kg; HCLF: -4.0 kg) and total percent body fat (HPLF: -1.5%; HCLF: -0.4%) significantly reduced from baseline to week 8 (P = .005 and P = .035, respectively). CONCLUSION: Both diets promoted > or = 5% loss in body weight and significantly reduced percent body fat.
RCT Entities:
CONTEXT: Incidence of insulin resistance (IR) in Americans is steadily rising. IR may be ameliorated with < or = 5% loss in body weight. OBJECTIVE: To examine effects of 2 weight-loss diets on body weight and composition in overweight adults with IR. DESIGN:Participants randomly assigned to a high-protein, low-fat (HPLF) or a high-carbohydrate, low-fat (HCLF) diet for 8 weeks. SETTING: All meals prepared and weighed in the metabolic kitchen at Arizona State University. Lunch consumed on-site; all other meals packaged for home consumption. PATIENTS: Twenty overweight, healthy participants with elevated fasting serum insulin (> or = 15 microU/L) were recruited. INTERVENTIONS: Both diets were low-fat (27% kcal from fat; < 7% saturated, < or = 10% monounsaturated, and < or = 10% polyunsaturated) and energy-restricted (energy levels were 1200, 1500, 1700 or 2000 kcal); HPLF: 32% protein, 41% carbohydrate; HCLF: 59% carbohydrate, 14% protein. Energy levels were assigned on the basis of participant's resting metabolic rate. MAIN OUTCOME MEASURES: Body composition, etabolic indices, fasting plasma glucose, and insulin. RESULTS: No significant differences were found in the main outcome measures between the diets. Body weight (HPLF: -4.9 kg; HCLF: -4.0 kg) and total percent body fat (HPLF: -1.5%; HCLF: -0.4%) significantly reduced from baseline to week 8 (P = .005 and P = .035, respectively). CONCLUSION: Both diets promoted > or = 5% loss in body weight and significantly reduced percent body fat.
Authors: Sally D Poppitt; Geraldine F Keogh; Andrew M Prentice; Desmond E M Williams; Heidi M W Sonnemans; Esther E J Valk; Elizabeth Robinson; Nicholas J Wareham Journal: Am J Clin Nutr Date: 2002-01 Impact factor: 7.045
Authors: Gary D Foster; Holly R Wyatt; James O Hill; Brian G McGuckin; Carrie Brill; B Selma Mohammed; Philippe O Szapary; Daniel J Rader; Joel S Edman; Samuel Klein Journal: N Engl J Med Date: 2003-05-22 Impact factor: 91.245
Authors: Emma Farnsworth; Natalie D Luscombe; Manny Noakes; Gary Wittert; Eleni Argyiou; Peter M Clifton Journal: Am J Clin Nutr Date: 2003-07 Impact factor: 7.045