| Literature DB >> 17415043 |
Piotr Nowak1, Babilonia Barqasho, Anders Sönnerborg.
Abstract
High mobility group box protein 1 (HMGB1) is a potent proinflammatory mediator. It has a dichotomic effect on HIV-1 replication in vitro but its role in vivo is unknown. Here we report the novel finding that plasma HMGB1 levels are elevated in HIV-1-infected patients, with the highest concentrations in patients with clinical complications. HMGB1 is likely to contribute to immunoactivation in HIV-1 infection in vivo.Entities:
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Year: 2007 PMID: 17415043 DOI: 10.1097/QAD.0b013e3280b079b6
Source DB: PubMed Journal: AIDS ISSN: 0269-9370 Impact factor: 4.177