BACKGROUND: A wide range in antibody titers has been found after immunization with the varicella vaccine, although the basis for these differences has not been described. METHODS: To evaluate the contribution of a genetic component in the immune response to the varicella vaccine, concordance for six-week postimmunization antibody titers was evaluated among 248 biologic siblings who participated in varicella vaccine clinical trials by comparing all pairs of siblings (151 pairs) to all possible unrelated, nonsibling pairs created from within this same cohort (30,477 pairs). RESULTS:Postimmunization antibody titers after 1 varicella vaccine dose were within the range observed historically among healthy vaccinees, with 85.4% of subjects having antibody responses greater than the approximate correlate of protection of 5 gpELISA units. Postimmunization antibody titers within sibling pairs clustered together more than or less than 10 gpELISA units when compared with within nonsibling pairs (P < 0.0001). Postimmunization titers within sibling pairs were also quantitatively closer together than were those within unrelated, nonsibling pairs (P = 0.022). The age-adjusted intraclass correlation coefficient indicated that the heritability of the varicella vaccine immune response is 45% (95% confidence interval of 15-75%). CONCLUSIONS: Similarities in siblings' response to varicella vaccine are supportive of the hypothesis that genetic factors play a role in the antibody response to the varicella vaccine.
RCT Entities:
BACKGROUND: A wide range in antibody titers has been found after immunization with the varicella vaccine, although the basis for these differences has not been described. METHODS: To evaluate the contribution of a genetic component in the immune response to the varicella vaccine, concordance for six-week postimmunization antibody titers was evaluated among 248 biologic siblings who participated in varicella vaccine clinical trials by comparing all pairs of siblings (151 pairs) to all possible unrelated, nonsibling pairs created from within this same cohort (30,477 pairs). RESULTS: Postimmunization antibody titers after 1 varicella vaccine dose were within the range observed historically among healthy vaccinees, with 85.4% of subjects having antibody responses greater than the approximate correlate of protection of 5 gpELISA units. Postimmunization antibody titers within sibling pairs clustered together more than or less than 10 gpELISA units when compared with within nonsibling pairs (P < 0.0001). Postimmunization titers within sibling pairs were also quantitatively closer together than were those within unrelated, nonsibling pairs (P = 0.022). The age-adjusted intraclass correlation coefficient indicated that the heritability of the varicella vaccine immune response is 45% (95% confidence interval of 15-75%). CONCLUSIONS: Similarities in siblings' response to varicella vaccine are supportive of the hypothesis that genetic factors play a role in the antibody response to the varicella vaccine.
Authors: Rohina Rubicz; Charles T Leach; Ellen Kraig; Nikhil V Dhurandhar; Ravindranath Duggirala; John Blangero; Robert Yolken; Harald H H Göring Journal: Hum Hered Date: 2011-10-11 Impact factor: 0.444
Authors: Rohina Rubicz; Robert Yolken; Eugene Drigalenko; Melanie A Carless; Thomas D Dyer; Jack Kent; Joanne E Curran; Matthew P Johnson; Shelley A Cole; Sharon P Fowler; Rector Arya; Sobha Puppala; Laura Almasy; Eric K Moses; Ellen Kraig; Ravindranath Duggirala; John Blangero; Charles T Leach; Harald H H Göring Journal: Eur J Hum Genet Date: 2015-03-11 Impact factor: 4.246
Authors: E Kathryn Miller; Logan Dumitrescu; Chelsea Cupp; Stacy Dorris; Sallee Taylor; Robert Sparks; Diane Fawkes; Virginia Frontiero; Anne M Rezendes; Colin Marchant; Kathryn M Edwards; Dana C Crawford Journal: Vaccine Date: 2011-03-09 Impact factor: 3.641
Authors: Luis M Franco; Kristine L Bucasas; Janet M Wells; Diane Niño; Xueqing Wang; Gladys E Zapata; Nancy Arden; Alexander Renwick; Peng Yu; John M Quarles; Molly S Bray; Robert B Couch; John W Belmont; Chad A Shaw Journal: Elife Date: 2013-07-16 Impact factor: 8.140