OBJECTIVE: Sepsis and its sequelae are the leading cause of death in critically ill patients. Discovery in the late 1990s of Toll-like receptors as primary sensors of microbial infection led to significant advances in understanding the pathogenesis of sepsis, including emerging differences between Gram-positive and Gram-negative infection and the potential for the manipulation of Toll-like receptors for the treatment of sepsis. This review describes these advances. METHODS: Bibliographic search of the literature since 1999, with particular emphasis on the conceptual and therapeutic implications of Toll-like receptors for patients with systemic sepsis. RESULTS AND CONCLUSIONS: Toll-like receptors initiate the inflammatory processes that underlie the clinical response to infection and therefore represent an important putative target for therapeutic intervention.
OBJECTIVE:Sepsis and its sequelae are the leading cause of death in critically illpatients. Discovery in the late 1990s of Toll-like receptors as primary sensors of microbial infection led to significant advances in understanding the pathogenesis of sepsis, including emerging differences between Gram-positive and Gram-negative infection and the potential for the manipulation of Toll-like receptors for the treatment of sepsis. This review describes these advances. METHODS: Bibliographic search of the literature since 1999, with particular emphasis on the conceptual and therapeutic implications of Toll-like receptors for patients with systemic sepsis. RESULTS AND CONCLUSIONS: Toll-like receptors initiate the inflammatory processes that underlie the clinical response to infection and therefore represent an important putative target for therapeutic intervention.
Authors: John V Pappachan; Tim G Coulson; Nicholas J A Child; David J Markham; Sarah M Nour; Mark C K Pulletz; Matthew J Rose-Zerilli; Kim de Courcey-Golder; Sheila J Barton; Ian A Yang; John W Holloway Journal: Immunogenetics Date: 2009-08-28 Impact factor: 2.846
Authors: A Mehl; S Harthug; S Lydersen; J Paulsen; B O Åsvold; E Solligård; J K Damås; T-H Edna Journal: Eur J Clin Microbiol Infect Dis Date: 2014-11-06 Impact factor: 3.267
Authors: Alexandra Bick; Willem Buys; Andrea Engler; Rabea Madel; Mazen Atia; Francesca Faro; Astrid M Westendorf; Andreas Limmer; Jan Buer; Frank Herbstreit; Carsten J Kirschning; Jürgen Peters Journal: PLoS One Date: 2022-08-18 Impact factor: 3.752