BACKGROUND: There remains no consensus about the optimal dietary composition for sustained weight loss. OBJECTIVE: The objective was to examine the effects of 2 dietary macronutrient patterns with different glycemic loads on adherence to a prescribed regimen of calorie restriction (CR), weight and fat loss, and related variables. DESIGN: A randomized controlled trial (RCT) of diets with a high glycemic load (HG) or a low glycemic load (LG) at 30% CR was conducted in 34 healthy overweight adults with a mean (+/-SD) age of 35 +/- 6 y and body mass index (kg/m(2)) of 27.6 +/- 1.4. All food was provided for 6 mo in diets controlled for confounding variables, and subjects self-administered the plans for 6 additional months. Primary and secondary outcomes included energy intake measured by doubly labeled water, body weight and fatness, hunger, satiety, and resting metabolic rate. RESULTS: All groups consumed significantly less energy during CR than at baseline (P < 0.01), but changes in energy intake, body weight, body fat, and resting metabolic rate did not differ significantly between groups. Both groups ate more energy than provided (eg, 21% and 28% CR at 3 mo and 16% and 17% CR at 6 mo with HG and LG, respectively). Percentage weight change at 12 mo was -8.04 +/- 4.1% in the HG group and -7.81 +/- 5.0% in the LG group. There was no effect of dietary composition on changes in hunger, satiety, or satisfaction with the amount and type of provided food during CR. CONCLUSIONS: These findings provide more detailed evidence to suggest that diets differing substantially in glycemic load induce comparable long-term weight loss.
RCT Entities:
BACKGROUND: There remains no consensus about the optimal dietary composition for sustained weight loss. OBJECTIVE: The objective was to examine the effects of 2 dietary macronutrient patterns with different glycemic loads on adherence to a prescribed regimen of calorie restriction (CR), weight and fat loss, and related variables. DESIGN: A randomized controlled trial (RCT) of diets with a high glycemic load (HG) or a low glycemic load (LG) at 30% CR was conducted in 34 healthy overweight adults with a mean (+/-SD) age of 35 +/- 6 y and body mass index (kg/m(2)) of 27.6 +/- 1.4. All food was provided for 6 mo in diets controlled for confounding variables, and subjects self-administered the plans for 6 additional months. Primary and secondary outcomes included energy intake measured by doubly labeled water, body weight and fatness, hunger, satiety, and resting metabolic rate. RESULTS: All groups consumed significantly less energy during CR than at baseline (P < 0.01), but changes in energy intake, body weight, body fat, and resting metabolic rate did not differ significantly between groups. Both groups ate more energy than provided (eg, 21% and 28% CR at 3 mo and 16% and 17% CR at 6 mo with HG and LG, respectively). Percentage weight change at 12 mo was -8.04 +/- 4.1% in the HG group and -7.81 +/- 5.0% in the LG group. There was no effect of dietary composition on changes in hunger, satiety, or satisfaction with the amount and type of provided food during CR. CONCLUSIONS: These findings provide more detailed evidence to suggest that diets differing substantially in glycemic load induce comparable long-term weight loss.
Authors: James Rochon; Connie W Bales; Eric Ravussin; Leanne M Redman; John O Holloszy; Susan B Racette; Susan B Roberts; Sai Krupa Das; Sergei Romashkan; Katherine M Galan; Evan C Hadley; William E Kraus Journal: J Gerontol A Biol Sci Med Sci Date: 2010-10-05 Impact factor: 6.053
Authors: Susan B Racette; Sai Krupa Das; Manjushri Bhapkar; Evan C Hadley; Susan B Roberts; Eric Ravussin; Carl Pieper; James P DeLany; William E Kraus; James Rochon; Leanne M Redman Journal: Am J Physiol Endocrinol Metab Date: 2011-11-29 Impact factor: 4.310
Authors: E E Blaak; J-M Antoine; D Benton; I Björck; L Bozzetto; F Brouns; M Diamant; L Dye; T Hulshof; J J Holst; D J Lamport; M Laville; C L Lawton; A Meheust; A Nilson; S Normand; A A Rivellese; S Theis; S S Torekov; S Vinoy Journal: Obes Rev Date: 2012-07-11 Impact factor: 9.213
Authors: Sai Krupa Das; Cheryl H Gilhooly; Julie K Golden; Anastassios G Pittas; Paul J Fuss; Gerard E Dallal; Megan A McCrory; Edward Saltzman; Susan B Roberts Journal: Open Nutr J Date: 2007-04-01
Authors: Kevin D Hall; Thomas Bemis; Robert Brychta; Kong Y Chen; Amber Courville; Emma J Crayner; Stephanie Goodwin; Juen Guo; Lilian Howard; Nicolas D Knuth; Bernard V Miller; Carla M Prado; Mario Siervo; Monica C Skarulis; Mary Walter; Peter J Walter; Laura Yannai Journal: Cell Metab Date: 2015-08-13 Impact factor: 27.287
Authors: Cheryl H Gilhooly; Sai Krupa Das; Julie K Golden; Megan A McCrory; James Rochon; James P DeLany; Alicia M Freed; Paul J Fuss; Gerard E Dallal; Edward Saltzman; Susan B Roberts Journal: Aging Clin Exp Res Date: 2008-12 Impact factor: 3.636