Literature DB >> 17413019

[123I]5-IA-85380 SPECT imaging of beta2-nicotinic acetylcholine receptor availability in the aging human brain.

Effie M Mitsis1, Kelly P Cosgrove, Julie K Staley, Erin B Frohlich, Frederic Bois, Gilles D Tamagnan, Kristina M Estok, John P Seibyl, Christopher H Van Dyck.   

Abstract

Human postmortem studies have reported decreases with age in high-affinity nicotine binding in brain. We have been investigating in vivo the availability of the beta(2)-containing nicotinic acetylcholine receptor (beta(2)-nAChR) in healthy nonsmokers (18-85 years of age) using [(123)I]5-IA-85380 SPECT imaging. Age and regional beta(2)-nAChR availability (V(T)(,)) have been observed to be inversely correlated in all brain regions analyzed, with decline ranging from 21% (cerebellum) to 36% (thalamus), or by up to 5% per decade of life. Preliminary results have confirmed postmortem reports of age-related decline in high-affinity nicotine binding with age and may elucidate the role of beta(2)-nAChRs in the cognitive decline associated with aging.

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Year:  2007        PMID： 17413019     DOI： 10.1196/annals.1379.015

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  9 in total

1.  Brain nicotinic acetylcholine receptor availability and response to smoking cessation treatment: a randomized trial.

Authors:  Arthur L Brody; Alexey G Mukhin; Michael S Mamoun; Trinh Luu; Meaghan Neary; Lidia Liang; Jennifer Shieh; Catherine A Sugar; Jed E Rose; Mark A Mandelkern
Journal:  JAMA Psychiatry       Date:  2014-07-01       Impact factor: 21.596

2.  Treatment for tobacco dependence: effect on brain nicotinic acetylcholine receptor density.

Authors:  Arthur L Brody; Alexey G Mukhin; Michael S Mamoun; Maggie Kozman; Jonathan Phuong; Meaghan Neary; Trinh Luu; Mark A Mandelkern
Journal:  Neuropsychopharmacology       Date:  2013-02-21       Impact factor: 7.853

Review 3.  Neuromodulation of reward-based learning and decision making in human aging.

Authors:  Ben Eppinger; Dorothea Hämmerer; Shu-Chen Li
Journal:  Ann N Y Acad Sci       Date:  2011-10       Impact factor: 5.691

4.  Single photon emission computed tomography experience with (S)-5-[(123)I]iodo-3-(2-azetidinylmethoxy)pyridine in the living human brain of smokers and nonsmokers.

Authors:  James Robert Brasić; Yun Zhou; John L Musachio; John Hilton; Hong Fan; Andrew Crabb; Christopher J Endres; Melvin J Reinhardt; Ahmet S Dogan; Mohab Alexander; Olivier Rousset; Marika A Maris; Jeffrey Galecki; Ayon Nandi; Dean F Wong
Journal:  Synapse       Date:  2009-04       Impact factor: 2.562

Review 5.  Dysfunctional Sensory Modalities, Locus Coeruleus, and Basal Forebrain: Early Determinants that Promote Neuropathogenesis of Cognitive and Memory Decline and Alzheimer's Disease.

Authors:  Mak Adam Daulatzai
Journal:  Neurotox Res       Date:  2016-06-23       Impact factor: 3.911

6.  Galantamine-induced improvements in cognitive function are not related to alterations in alpha(4)beta (2) nicotinic receptors in early Alzheimer's disease as measured in vivo by 2-[18F]fluoro-A-85380 PET.

Authors:  J R Ellis; P J Nathan; V L Villemagne; R S Mulligan; T Saunder; K Young; C L Smith; J Welch; M Woodward; K A Wesnes; G Savage; C C Rowe
Journal:  Psychopharmacology (Berl)       Date:  2008-10-24       Impact factor: 4.530

7.  Age-related decline in nicotinic receptor availability with [(123)I]5-IA-85380 SPECT.

Authors:  Effie M Mitsis; Kelly P Cosgrove; Julie K Staley; Frederic Bois; Erin B Frohlich; Gilles D Tamagnan; Kristina M Estok; John P Seibyl; Christopher H van Dyck
Journal:  Neurobiol Aging       Date:  2008-02-01       Impact factor: 4.673

Review 8.  Mechanisms of GABAergic and cholinergic neurotransmission in auditory thalamus: Impact of aging.

Authors:  B D Richardson; S Y Sottile; D M Caspary
Journal:  Hear Res       Date:  2020-06-11       Impact factor: 3.672

Review 9.  Cholinergic Modulation of Glial Function During Aging and Chronic Neuroinflammation.

Authors:  Rashmi Gamage; Ingrid Wagnon; Ilaria Rossetti; Ryan Childs; Garry Niedermayer; Rose Chesworth; Erika Gyengesi
Journal:  Front Cell Neurosci       Date:  2020-10-15       Impact factor: 5.505
  9 in total

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