Literature DB >> 17413010

Impaired recognition memory and decreased prefrontal cortex spine density in aged female rats.

Maureen Wallace1, Maya Frankfurt, Adolfo Arellanos, Tomoko Inagaki, Victoria Luine.   

Abstract

Aged F344 female rats (21 months) showed decreased performance, as compared to young rats (4 months), on an object recognition memory task. Golgi impregnation measured dendritic spine density of pyramidal neurons in the prefrontal cortex (layer II-III), a brain area important for recognition memory. Densities of spines in aged rats were 16% lower in tertiary, apical dendrites, but not significantly different in secondary basal dendrites. Concurrent measures of memory and spine density in the young and aged subjects show that age-related declines in recognition memory are associated with decreased cortical spine density.

Entities:  

Mesh：

Year:  2007        PMID： 17413010     DOI： 10.1196/annals.1379.026

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  29 in total

1.  Long-term replacement of estrogen in combination with medroxyprogesterone acetate improves acquisition of an alternation task in middle-aged female rats.

Authors:  Nioka C Chisholm; Janice M Juraska
Journal:  Behav Neurosci       Date:  2011-12-05       Impact factor: 1.912

Review 2.  Role of androgens and the androgen receptor in remodeling of spine synapses in limbic brain areas.

Authors:  Tibor Hajszan; Neil J MacLusky; Csaba Leranth
Journal:  Horm Behav       Date:  2007-12-31       Impact factor: 3.587

3.  Effects of long-term treatment with estrogen and medroxyprogesterone acetate on synapse number in the medial prefrontal cortex of aged female rats.

Authors:  Nioka C Chisholm; Janice M Juraska
Journal:  Menopause       Date:  2012-07       Impact factor: 2.953

Review 4.  Estrogens and age-related memory decline in rodents: what have we learned and where do we go from here?

Authors:  Karyn M Frick
Journal:  Horm Behav       Date:  2008-09-16       Impact factor: 3.587

Review 5.  The evolving role of dendritic spines and memory: Interaction(s) with estradiol.

Authors:  Maya Frankfurt; Victoria Luine
Journal:  Horm Behav       Date:  2015-05-17       Impact factor: 3.587

6.  Dendritic Spine Density and Dynamics of Layer 5 Pyramidal Neurons of the Primary Motor Cortex Are Elevated With Aging.

Authors:  A M Davidson; H Mejía-Gómez; M Jacobowitz; R Mostany
Journal:  Cereb Cortex       Date:  2020-03-21       Impact factor: 5.357

7.  Males, but not females, lose tyrosine hydroxylase fibers in the medial prefrontal cortex and are impaired on a delayed alternation task during aging.

Authors:  Nioka C Chisholm; Taehyeon Kim; Janice M Juraska
Journal:  Behav Brain Res       Date:  2013-01-15       Impact factor: 3.332

8.  Calorie restriction down-regulates expression of the iron regulatory hormone hepcidin in normal and D-galactose-induced aging mouse brain.

Authors:  Shougang Wei; Wenli Shi; Man Li; Qian Gao
Journal:  Rejuvenation Res       Date:  2014-02       Impact factor: 4.663

Review 9.  Structural and functional plasticity of dendritic spines - root or result of behavior?

Authors:  C D Gipson; M F Olive
Journal:  Genes Brain Behav       Date:  2016-10-02       Impact factor: 3.449

10.  The effects of long-term treatment with estradiol and medroxyprogesterone acetate on tyrosine hydroxylase fibers and neuron number in the medial prefrontal cortex of aged female rats.

Authors:  Nioka C Chisholm; Alexandria R Packard; Wendy A Koss; Janice M Juraska
Journal:  Endocrinology       Date:  2012-08-17       Impact factor: 4.736
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.