BACKGROUND: An important role of CD36 in muscle fatty acid (FA) uptake has been shown in CD36-knockout or CD36-overexpressed mice. FA is a predominant substrate in energy production during light exercise below the anaerobic threshold (AT). We studied whether aerobic exercise capacity in humans could be affected by CD36 deficiency. METHODS: We investigated the ventilatory threshold (VT) and serum FA changes in normal participants (n = 22) and participants with CD36 deficiency (n = 12) during pedalling on a cycle ergometer. RESULTS: In participants with CD36 deficiency, FA levels were not reduced at peak work rate, whereas FA levels decreased by about 50% in normal participants. Participants with CD36 deficiency showed significantly lower VT than normal participants. A significant correlation was observed between VT and percentage changes in FA at peak work rate. CONCLUSION: This study found reduced FA utilisation and an attenuated aerobic exercise capacity in CD36 deficiency, indicating that CD36-mediated FA oxidation is an important determinant for aerobic exercise capacity in humans.
BACKGROUND: An important role of CD36 in muscle fatty acid (FA) uptake has been shown in CD36-knockout or CD36-overexpressed mice. FA is a predominant substrate in energy production during light exercise below the anaerobic threshold (AT). We studied whether aerobic exercise capacity in humans could be affected by CD36 deficiency. METHODS: We investigated the ventilatory threshold (VT) and serum FA changes in normal participants (n = 22) and participants with CD36 deficiency (n = 12) during pedalling on a cycle ergometer. RESULTS: In participants with CD36 deficiency, FA levels were not reduced at peak work rate, whereas FA levels decreased by about 50% in normal participants. Participants with CD36 deficiency showed significantly lower VT than normal participants. A significant correlation was observed between VT and percentage changes in FA at peak work rate. CONCLUSION: This study found reduced FA utilisation and an attenuated aerobic exercise capacity in CD36 deficiency, indicating that CD36-mediated FA oxidation is an important determinant for aerobic exercise capacity in humans.
Authors: H Yanai; H Chiba; H Fujiwara; M Morimoto; Y Takahashi; S P Hui; H Fuda; H Akita; T Kurosawa; K Kobayashi; K Matsuno Journal: Thromb Haemost Date: 2001-10 Impact factor: 5.249
Authors: Arend Bonen; Shannon E Campbell; Carley R Benton; Adrian Chabowski; Susan L M Coort; Xiao-Xia Han; Debby P Y Koonen; Jan F C Glatz; Joost J F P Luiken Journal: Proc Nutr Soc Date: 2004-05 Impact factor: 6.297
Authors: Andrew E Fry; Anita Ghansa; Kerrin S Small; Alejandro Palma; Sarah Auburn; Mahamadou Diakite; Angela Green; Susana Campino; Yik Y Teo; Taane G Clark; Anna E Jeffreys; Jonathan Wilson; Muminatou Jallow; Fatou Sisay-Joof; Margaret Pinder; Michael J Griffiths; Norbert Peshu; Thomas N Williams; Charles R Newton; Kevin Marsh; Malcolm E Molyneux; Terrie E Taylor; Kwadwo A Koram; Abraham R Oduro; William O Rogers; Kirk A Rockett; Pardis C Sabeti; Dominic P Kwiatkowski Journal: Hum Mol Genet Date: 2009-04-29 Impact factor: 6.150