| Literature DB >> 17412649 |
Sarah Lambert1, Benoît Froget, Antony M Carr.
Abstract
The arrest of DNA replication by DNA damage, nucleotide depletion, DNA-protein complexes or following clashes between transcription and replication factors all have the capacity to promote genome instability. In this review, we discuss how DNA replication is regulated by the checkpoint pathways that stabilise arrested replication forks and the recombination factors that process specific DNA structures resulting from fork arrest. We examine what is known about the interplay between the checkpoints and the recombination apparatus and review the evidence for a recombination-based fork restart pathway in eukaryotes.Entities:
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Year: 2007 PMID： 17412649 DOI： 10.1016/j.dnarep.2007.02.024
Source DB: PubMed Journal: DNA Repair (Amst) ISSN： 1568-7856