Literature DB >> 17412455

Effects of statins on alpha7 nicotinic receptor, cholinesterase and alpha-form of secreted amyloid precursor peptide in SH-SY5Y cells.

Julia Roensch1, Milita Crisby, Agneta Nordberg, Yan Xiao, Lan-Jiang Zhang, Zhi-Zhong Guan.   

Abstract

In order to reveal the neuroprotective effects of statins that could be of interest for the prevention and treatment of Alzheimer's disease (AD), we investigated the expression of nicotinic acetylcholine receptors (nAChRs) detected by RT-PCR, the activity of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) by colorimetric determination, and the levels of the alpha-form of secreted beta-amyloid precursor protein (alphaAPPs) by Western blotting in neuroblastoma (SH-SY5Y) cells exposed to lovastatin, atorvastatin, rosuvastatin and simvastatin, respectively. The results indicated that all statins studied, both lipophilic and hydrophilic, induced high expression of alpha7 nAChR, decreased cholinesterase activities, and increased alphaAPPs, which suggests that statins might play important neuroprotective roles in AD treatment.

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Year:  2007        PMID： 17412455     DOI： 10.1016/j.neuint.2007.02.001

Source DB:  PubMed          Journal:  Neurochem Int        ISSN： 0197-0186            Impact factor:   3.921


  7 in total

1.  Reduction of brain beta-amyloid (Abeta) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, through increase in degradation of amyloid precursor protein C-terminal fragments (APP-CTFs) and Abeta clearance.

Authors:  Mitsuru Shinohara; Naoyuki Sato; Hitomi Kurinami; Daisuke Takeuchi; Shuko Takeda; Munehisa Shimamura; Toshihide Yamashita; Yasuo Uchiyama; Hiromi Rakugi; Ryuichi Morishita
Journal:  J Biol Chem       Date:  2010-05-14       Impact factor: 5.157

2.  Preventing expression of the nicotinic receptor subunit α7 in SH-SY5Y cells with interference RNA indicates that this receptor may protect against the neurotoxicity of Aβ.

Authors:  Xiao-Lan Qi; Kai Ou-Yang; Jia-Mou Ren; Chang-Xue Wu; Yan Xiao; Yi Li; Zhi-Zhong Guan
Journal:  Neurochem Res       Date:  2013-02-21       Impact factor: 3.996

3.  Simvastatin Enhances Spatial Memory and Long-Term Potentiation in Hippocampal CA1 via Upregulation of α7 Nicotinic Acetylcholine Receptor.

Authors:  Tingting Chen; Conghui Wang; Sha Sha; Libin Zhou; Lei Chen; Ling Chen
Journal:  Mol Neurobiol       Date:  2015-07-22       Impact factor: 5.590

4.  Rosuvastatin induces delayed preconditioning against L-glutamate excitotoxicity in cultured cortical neurons.

Authors:  Ferenc Domoki; Béla Kis; Tamás Gáspár; James A Snipes; Ferenc Bari; David W Busija
Journal:  Neurochem Int       Date:  2009-11-17       Impact factor: 3.921

5.  Roles of Simvastatin and Sildenafil in Modulation of Cranial Irradiation-Induced Bystander Multiple Organs Injury in Rats.

Authors:  Engy Refaat Rashed; Mohamed Khairy Abdel-Rafei; Noura Magdy Thabet
Journal:  Inflammation       Date:  2021-08-21       Impact factor: 4.092

Review 6.  Possible modification of Alzheimer's disease by statins in midlife: interactions with genetic and non-genetic risk factors.

Authors:  Mitsuru Shinohara; Naoyuki Sato; Munehisa Shimamura; Hitomi Kurinami; Toshimitsu Hamasaki; Amarnath Chatterjee; Hiromi Rakugi; Ryuichi Morishita
Journal:  Front Aging Neurosci       Date:  2014-04-23       Impact factor: 5.750

7.  Lovastatin Differentially Regulates α7 and α4 Neuronal Nicotinic Acetylcholine Receptor Levels in Rat Hippocampal Neurons.

Authors:  Virginia Borroni; Constanza Kamerbeek; María F Pediconi; Francisco J Barrantes
Journal:  Molecules       Date:  2020-10-20       Impact factor: 4.411
  7 in total

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