BACKGROUND: The MNS16A polymorphism is located in the downstream region of the hTERT gene and affects telomerase activity. METHODS: MNS16A has been investigated as a potential risk factor and/or prognostic marker for malignant glioma in a cohort of 352 patients (205 glioblastoma, 147 anaplastic gliomas) and 305 controls. RESULTS: The S ("short") allele (which results in a higher telomerase activity) was significantly more frequent in glioma patients compared to the control population (278/704=39.5% vs. 200/610=32.8%; P=0.012). The odd ratios were 1 for LL (taken as reference), 1.33 [0.96; 1.84] for SL and 2.05 [1.22; 3.44] for SS. However, in contrast to a previous report, no significant difference of survival was found between SS, LL and SL allelotypes. CONCLUSION: We found here the short allele of MNS16A more frequent in glioma patients, but it did not seem to be predictive of survival.
BACKGROUND: The MNS16A polymorphism is located in the downstream region of the hTERT gene and affects telomerase activity. METHODS: MNS16A has been investigated as a potential risk factor and/or prognostic marker for malignant glioma in a cohort of 352 patients (205 glioblastoma, 147 anaplastic gliomas) and 305 controls. RESULTS: The S ("short") allele (which results in a higher telomerase activity) was significantly more frequent in gliomapatients compared to the control population (278/704=39.5% vs. 200/610=32.8%; P=0.012). The odd ratios were 1 for LL (taken as reference), 1.33 [0.96; 1.84] for SL and 2.05 [1.22; 3.44] for SS. However, in contrast to a previous report, no significant difference of survival was found between SS, LL and SL allelotypes. CONCLUSION: We found here the short allele of MNS16A more frequent in gliomapatients, but it did not seem to be predictive of survival.
Authors: Luo Wang; Qingyi Wei; Li-E Wang; Kenneth D Aldape; Yumei Cao; M Fatih Okcu; Kenneth R Hess; Randa El-Zein; Mark R Gilbert; Shiao Y Woo; Sujit S Prabhu; Greg N Fuller; Melissa L Bondy Journal: J Clin Oncol Date: 2006-04-01 Impact factor: 44.544
Authors: A Tchirkov; C Rolhion; J-L Kémény; B Irthum; S Puget; T Khalil; O Chinot; F Kwiatkowski; B Périssel; P Vago; P Verrelle Journal: Br J Cancer Date: 2003-02-24 Impact factor: 7.640
Authors: Jing Shen; Marilie D Gammon; Hui-Chen Wu; Mary Beth Terry; Qiao Wang; Patrick T Bradshaw; Susan L Teitelbaum; Alfred I Neugut; Regina M Santella Journal: Cancer Epidemiol Biomarkers Prev Date: 2010-01 Impact factor: 4.254