| Literature DB >> 17409743 |
Hirokazu Hirata1, Yoshinobu Murakami, Yoshiaki Miyamoto, Mako Tosaka, Kayoko Inoue, Ayako Nagahashi, Lars Martin Jakt, Takayuki Asahara, Hiroo Iwata, Yoshiki Sawa, Shin Kawamata.
Abstract
ALCAM (activated leukocyte cell adhesion molecule, CD166) belongs to the immunoglobulin superfamily and is involved in axon guidance, hematopoiesis, immune response and tumor metastasis. During embryogenesis, mRNA encoding ALCAM was expressed in the cardiac crescent and the neural groove at embryonic day (E) 7.75 and predominately in the tubular heart at E8.5. A newly generated monoclonal antibody against the ALCAM molecule (ALC-48) exclusively stained cardiomyocytes at E8.25-10.5. However, ALCAM expression was lost by cardiomyocytes by E12.5 and its expression shifts to a variety of organs during later stages. ALCAM was found to be a prominent surface marker for cardiomyocytes in early embryonic hearts. The transient expression of ALCAM during early developmental stages marks specific developmental stages in cardiomyocyte differentiation. Copyright 2007 S. Karger AG, Basel.Entities:
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Year: 2006 PMID： 17409743 DOI： 10.1159/000099624
Source DB: PubMed Journal: Cells Tissues Organs ISSN： 1422-6405 Impact factor: 2.481