Literature DB >> 17409572

An 18-norspirostanol saponin with inhibitory action against COX-2 production from the underground part of Trillium tschonoskii.

Junzhi Wang1, Kun Zou, Yanming Zhang, Chuang Liu, Jun Wu, Yuan Zhou, Feijun Dan, Yaxiong Zhang.   

Abstract

A novel 18-norspirostanol saponin (1), along with Trillenoside A (2), was obtained from the underground parts of Trillium tschonoskii MAXIM., collected in Shennongjia Forest District, China. Based on the chemical and spectroscopic evidences, their structures were determined as shown in Fig. 1. 1 and 2 displayed marked inhibitory action towards COX-2 production in macrophagocytes of the mouse abdominal cavity stimulated by LPS at 10 microg/ml.

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Year:  2007        PMID: 17409572     DOI: 10.1248/cpb.55.679

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN: 0009-2363            Impact factor:   1.645


  5 in total

1.  Trillin prevents proliferation and induces apoptosis through inhibiting STAT3 nuclear translocation in hepatoma carcinoma cells.

Authors:  Guangjie Zhan; Jun Hu; Benjian Xiao; Xianli Wang; Zixian Yang; Guohua Yang; Lili Lu
Journal:  Med Oncol       Date:  2020-04-08       Impact factor: 3.064

2.  New polyhydroxylated furostanol saponins with inhibitory action against NO production from Tupistra chinensis rhizomes.

Authors:  Lan-Lan Xu; Kun Zou; Jun-Zhi Wang; Jun Wu; Yuan Zhou; Fei-Jun Dan; Jing Yang
Journal:  Molecules       Date:  2007-08-23       Impact factor: 4.411

Review 3.  Bioactive Steroids and Saponins of the Genus Trillium.

Authors:  Shafiq Ur Rahman; Muhammad Ismail; Muhammad Khurram; Irfan Ullah; Fazle Rabbi; Marcello Iriti
Journal:  Molecules       Date:  2017-12-05       Impact factor: 4.411

4.  Beneficial Effects of Trillium govanianum Rhizomes in Pain and Inflammation.

Authors:  Shafiq Ur Rahman; Achyut Adhikari; Muhammad Ismail; Muhammad Raza Shah; Muhammad Khurram; Muhammad Shahid; Farman Ali; Abdul Haseeb; Fazal Akbar; Marcello Iriti
Journal:  Molecules       Date:  2016-08-20       Impact factor: 4.411

5.  Three New Sesquiterpene Glycosides from the Rhizomes of Trillium tschonoskii.

Authors:  Jie Yang; Yin-Jun Yang; Xin-Guang Sun; Jie Zhang; Yang Zhao; Bei Wang; Qian-Zhi Ding; Bao-Lin Guo; Bai-Ping Ma
Journal:  Molecules       Date:  2017-08-02       Impact factor: 4.411

  5 in total

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