Literature DB >> 17409565

Hydrolyzed metabolites of thalidomide: synthesis and TNF-alpha production-inhibitory activity.

Takanori Nakamura1, Tomomi Noguchi, Hiroyuki Miyachi, Yuichi Hashimoto.   

Abstract

Putative hydrolyzed metabolites of thalidomide were prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-alpha production in the human monocytic leukemia cell line THP-1 was evaluated. Alpha-(2-Carboxybenzamido)glutarimide was a more potent TNF-alpha production inhibitor than thalidomide.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17409565     DOI： 10.1248/cpb.55.651

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  3 in total

1.  Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation.

Authors:  Christina Therapontos; Lynda Erskine; Erin R Gardner; William D Figg; Neil Vargesson
Journal:  Proc Natl Acad Sci U S A       Date:  2009-05-11       Impact factor: 11.205

2.  Crystal structure of (S)-4-carbamoyl-4-(1,3-dioxo-isoindolin-2-yl)butanoic acid.

Authors:  Kohei Otogawa; Kazuhiko Ishikawa; Motoo Shiro; Toru Asahi
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-01-01

3.  De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives.

Authors:  Christopher Heim; Dimanthi Pliatsika; Farnoush Mousavizadeh; Kerstin Bär; Birte Hernandez Alvarez; Athanassios Giannis; Marcus D Hartmann
Journal:  J Med Chem       Date:  2019-07-12       Impact factor: 7.446
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.