| Literature DB >> 17408464 |
Marie-Christine Kyrtsonis1, Theodoros P Vassilakopoulos, Nicoletta Kafasi, Sotirios Sachanas, Tatiana Tzenou, Argiroula Papadogiannis, Zacharoula Galanis, Christina Kalpadakis, Maria Dimou, Elias Kyriakou, Maria K Angelopoulou, Maria N Dimopoulou, Marina P Siakantaris, Evangelia M Dimitriadou, Styliani I Kokoris, Panayiotis Panayiotidis, Gerassimos A Pangalis.
Abstract
The prognostic value of baseline serum free light chain ratio (sFLCR) was investigated in 94 multiple myeloma (MM) patients. sFLCR was calculated as kappa/lambda or lambda/kappa, depending on the patients' dominating monoclonal light chain. Median baseline sFLCR was 3.57 in kappa-MM patients, 45.09 in lambda-MM. 'High' sFLCR (> or = the observed median value for kappa- and lambda-MM respectively) correlated with elevated serum creatinine and lactate dehydrogenase, extensive marrow infiltration and light chain type MM. The 5-year disease-specific survival was 82% and 30% in patients with sFLCR lower than and equal or greater than the median, respectively (P = 0.0001). sFLCR was an independent prognostic factor.Entities:
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Year: 2007 PMID： 17408464 DOI： 10.1111/j.1365-2141.2007.06561.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998