OBJECTIVE: To investigate the association of HLA class I and II alleles with generalized vitiligo in ethnic Han Chinese in north China. METHODS: By employing polymerase chain reaction sequence-specific primer (PCR-SSP) procedure 34 generalized vitiligo patients in north China were studied for HLA I and II alleles and were compared with 102 healthy controls. RESULTS: The allelic frequencies of HLA-A*30, Cw*06, DRB1*07, and DQB1*0201 were increased significantly in generalized vitiligo and especially in the patients without family history compared with the controls. CONCLUSION: These alleles positively associated with generalized vitiligo in Chinese Han patients in north China, might provide clues to reveal the susceptibility gene(s) of vitiligo in Chinese and as well as the immunnogenetic mechanisms of disease.
OBJECTIVE: To investigate the association of HLA class I and II alleles with generalized vitiligo in ethnic Han Chinese in north China. METHODS: By employing polymerase chain reaction sequence-specific primer (PCR-SSP) procedure 34 generalized vitiligo patients in north China were studied for HLA I and II alleles and were compared with 102 healthy controls. RESULTS: The allelic frequencies of HLA-A*30, Cw*06, DRB1*07, and DQB1*0201 were increased significantly in generalized vitiligo and especially in the patients without family history compared with the controls. CONCLUSION: These alleles positively associated with generalized vitiligo in Chinese Han patients in north China, might provide clues to reveal the susceptibility gene(s) of vitiligo in Chinese and as well as the immunnogenetic mechanisms of disease.
Authors: Jin Tang; Jian Lan Liu; Cheng Zhang; Da Yan Hu; Su Min He; Xian Bo Zuo; Pei Guang Wang; Liang Dan Sun; Xue Jun Zhang; Sen Yang Journal: Mol Biol Rep Date: 2013-03-21 Impact factor: 2.316