BACKGROUND: Acute viral hepatitis due to hepatitis A virus is a self-limited illness that infrequently has a severe clinical course. METHODS: We analyzed the virological characteristics of acute hepatitis A in a patient with a severe clinical presentation (peak total and conjugated bilirubin levels, 65.5 mg/dL and 40.1 mg/dL, respectively) and a course of disease that lasted 7 months. RESULTS: Hepatitis A virus sequencing revealed coinfection with 2 subgenotypes of hepatitis A virus (Ia and Ib) as etiological factors of the illness. CONCLUSIONS: Hepatitis A virus Ia and Ib coinfection may have accounted for the prolonged and severe course of illness.
BACKGROUND: Acute viral hepatitis due to hepatitis A virus is a self-limited illness that infrequently has a severe clinical course. METHODS: We analyzed the virological characteristics of acute hepatitis A in a patient with a severe clinical presentation (peak total and conjugated bilirubin levels, 65.5 mg/dL and 40.1 mg/dL, respectively) and a course of disease that lasted 7 months. RESULTS:Hepatitis A virus sequencing revealed coinfection with 2 subgenotypes of hepatitis A virus (Ia and Ib) as etiological factors of the illness. CONCLUSIONS:Hepatitis A virus Ia and Ib coinfection may have accounted for the prolonged and severe course of illness.
Authors: Joo Il Kim; Yun Soo Kim; Young Kul Jung; Oh Sang Kwon; Yeon Suk Kim; Yang Suh Ku; Duck Joo Choi; Ju Hyun Kim Journal: Korean J Hepatol Date: 2010-09
Authors: Eileen L Yoon; Hyung Joon Yim; Seung Young Kim; Jeong Han Kim; Ju-Han Lee; Young Sun Lee; Hyun Jung Lee; Sung Woo Jung; Sang Woo Lee; Jai Hyun Choi Journal: Korean J Hepatol Date: 2010-09
Authors: Hee Sup Kim; Sook Hyang Jeong; Je Hyuck Jang; Hyung Joon Myung; Jin Wook Kim; Soo Mee Bang; Sang Hoon Song; Haeryoung Kim; Hae Sun Yun Journal: Korean J Hepatol Date: 2011-12
Authors: Elisabeth Lang; Vitaly I Pozdeev; Prashant V Shinde; Haifeng C Xu; Balamurugan Sundaram; Yuan Zhuang; Gereon Poschmann; Jun Huang; Kai Stühler; Aleksandra A Pandyra; Verena Keitel; Dieter Häussinger; Karl S Lang; Philipp A Lang Journal: Sci Rep Date: 2018-08-15 Impact factor: 4.379