| Literature DB >> 17406980 |
Virginia Andreoli1, Giuseppe Nicoletti, Nelide Romeo, Francesca Condino, Antonella La Russa, Maria Liguori, Ida Manna, Patrizia Spadafora, Aldo Quattrone, Rita Cittadella.
Abstract
Tumor Necrosis Factor Receptor Super Family 6 gene (TNFRSF6), also known as FAS, encodes the Fas antigen, a cell surface receptor mediating cell apoptosis, situated on chromosome 10q located near the region of linkage to sporadic Alzheimer's disease (sAD). FAS levels have been reported elevated in the brain of AD patients. Due to both positional and pathobiological criteria, the association of the FAS antigen with this pathology is of great interest. We have tested two SNPs in the FAS gene in 223 Italian patients with non-familial AD from Southern Italy (Calabria region) and 211 healthy control subjects. No significant differences in allelic and genotypic distributions were found between cases and controls, or late and early-onset AD patients, thus suggesting that these polymorphisms do not represent an AD risk factor in our population.Entities:
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Year: 2007 PMID： 17406980 DOI： 10.1007/s11064-007-9329-6
Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996