| Literature DB >> 17406976 |
Lusine Danielyan1, Ali Lourhmati, Stephan Verleysdonk, Daniela Kabisch, Barbara Proksch, Ulrike Thiess, Sumaira Umbreen, Boris Schmidt, Christoph H Gleiter.
Abstract
The present study investigated the role of angiotensin receptors (AT-R) in the survival and inflammatory response of astroglia upon hypoxic injury. Exposure of rat astroglial primary cultures (APC) to hypoxic conditions (HC) led to decreased viability of the cells and to a 3.5-fold increase in TNF-alpha release. AT-R type1 (AT1-R) antagonist losartan and its metabolite EXP3174 decrease the LDH release (by 36 +/- 9%; 45 +/- 6%) from APC under HC. Losartan diminished TNF-alpha release (by 40 +/- 15%) and the number of TUNEL-cells by 204 +/- 38% under HC, alone and together with angiotensin II (ATII), while EXP3174 was dependent on ATII for its effect on TNF-alpha. The AT2-R antagonist, PD123.319, did not influence the release of LDH and TNF-alpha under normoxic (NC) and HC. These data suggest that AT1-R may decrease the susceptibility of astrocytes to hypoxic injury and their propensity to release TNF-alpha. AT1-R antagonists may therefore be of therapeutic value during hypoxia-associated neurodegeneration.Entities:
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Year: 2007 PMID： 17406976 DOI： 10.1007/s11064-007-9337-6
Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996