Literature DB >> 17404977

Cultivation of Tripterygium wilfordii Tissue Cultures for the Production of the Cytotoxic Diterpene Tripdiolide.

J P Kutney1, L S Choi, R Duffin, G Hewitt, N Kawamura, T Kurihara, P Salisbury, R Sindelar, K L Stuart, P M Townsley, W T Chalmers, F Webster, G G Jacoli.   

Abstract

The production of the cytotoxic agent tripdiolide employing plant tissue cultures of TRIPTERYGIUM WILFORDII is demonstrated. Detailed investigations of a developed cell line of T. WILFORDII in terms of tripdiolide production versus variations in growth conditions, for example media composition, are presented. Also the age and size of the inoculum and the incubation period with respect to tripdiolide formation are evaluated.

Entities:  

Year:  1983        PMID: 17404977     DOI: 10.1055/s-2007-969913

Source DB:  PubMed          Journal:  Planta Med        ISSN: 0032-0943            Impact factor:   3.352


  2 in total

1.  Anti-inflammatory oleanane triterpenes from Tripterygium wilfordii cell suspension cultures by fungal elicitation.

Authors:  J P Kutney; M D Samija; G M Hewitt; E C Bugante; H Gu
Journal:  Plant Cell Rep       Date:  1993-04       Impact factor: 4.570

2.  Tripterygium wilfordii cytochrome P450s catalyze the methyl shift and epoxidations in the biosynthesis of triptonide.

Authors:  Nikolaj Lervad Hansen; Louise Kjaerulff; Quinn Kalby Heck; Victor Forman; Dan Staerk; Birger Lindberg Møller; Johan Andersen-Ranberg
Journal:  Nat Commun       Date:  2022-08-25       Impact factor: 17.694

  2 in total

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