Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Sickle cell disease: old discoveries, new concepts, and future promise.

Literature DB >> 17404610

Sickle cell disease: old discoveries, new concepts, and future promise.

Abstract

The discovery of the molecular basis of sickle cell disease was an important landmark in molecular medicine. The modern tools of molecular and cellular biology have refined our understanding of its pathophysiology and facilitated the development of new therapies. In this review, we discuss some of the important advances in this field and the impediments that limit the impact of these advances.

Mesh：

Substances：
Globins

Year: 2007 PMID： 17404610 PMCID： PMC1838946 DOI： 10.1172/JCI30920

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

125 in total

1. Fetal hemoglobin levels in sickle cell disease and normal individuals are partially controlled by an X-linked gene located at Xp22.2.

Authors: G J Dover; K D Smith; Y C Chang; S Purvis; A Mays; D A Meyers; C Sheils; G Serjeant
Journal: Blood Date: 1992-08-01 Impact factor: 22.113

2. Prediction of adverse outcomes in children with sickle cell disease.

Authors: S T Miller; L A Sleeper; C H Pegelow; L E Enos; W C Wang; S J Weiner; D L Wethers; J Smith; T R Kinney
Journal: N Engl J Med Date: 2000-01-13 Impact factor: 91.245

3. Band 3 peptides block the adherence of sickle cells to endothelial cells in vitro.

Authors: B J Thevenin; I Crandall; S K Ballas; I W Sherman; S B Shohet
Journal: Blood Date: 1997-11-15 Impact factor: 22.113

4. Long-term hydroxyurea therapy for infants with sickle cell anemia: the HUSOFT extension study.

Authors: Jane S Hankins; Russell E Ware; Zora R Rogers; Lynn W Wynn; Peter A Lane; J Paul Scott; Winfred C Wang
Journal: Blood Date: 2005-10-01 Impact factor: 22.113

Review 5. Recent advances in globin gene transfer for the treatment of beta-thalassemia and sickle cell anemia.

Authors: Michel Sadelain
Journal: Curr Opin Hematol Date: 2006-05 Impact factor: 3.284

6. A multiparameter analysis of sickle erythrocytes in patients undergoing hydroxyurea therapy.

Authors: K R Bridges; G D Barabino; C Brugnara; M R Cho; G W Christoph; G Dover; B M Ewenstein; D E Golan; C R Guttmann; J Hofrichter; R V Mulkern; B Zhang; W A Eaton
Journal: Blood Date: 1996-12-15 Impact factor: 22.113

7. Results of minimally toxic nonmyeloablative transplantation in patients with sickle cell anemia and beta-thalassemia.

Authors: Robert Iannone; James F Casella; Ephraim J Fuchs; Allen R Chen; Richard J Jones; Ann Woolfrey; Michael Amylon; Keith M Sullivan; Rainer F Storb; Mark C Walters
Journal: Biol Blood Marrow Transplant Date: 2003-08 Impact factor: 5.742

8. 5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia.

Authors: T J Ley; J DeSimone; C T Noguchi; P H Turner; A N Schechter; P Heller; A W Nienhuis
Journal: Blood Date: 1983-08 Impact factor: 22.113

9. Molecular mechanisms of human hemoglobin switching: selective undermethylation and expression of globin genes in embryonic, fetal, and adult erythroblasts.

Authors: F Mavilio; A Giampaolo; A Carè; G Migliaccio; M Calandrini; G Russo; G L Pagliardi; G Mastroberardino; M Marinucci; C Peschle
Journal: Proc Natl Acad Sci U S A Date: 1983-11 Impact factor: 11.205

10. Adhesion of sickle red blood cells and damage to interleukin-1 beta stimulated endothelial cells under flow in vitro.

Authors: M Natarajan; M M Udden; L V McIntire
Journal: Blood Date: 1996-06-01 Impact factor: 22.113

116 in total

1. Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium.

Authors: Rahima Zennadi; Erin J Whalen; Erik J Soderblom; Susan C Alexander; J Will Thompson; Laura G Dubois; M Arthur Moseley; Marilyn J Telen
Journal: Blood Date: 2011-12-06 Impact factor: 22.113

2. Carbon-fiber microelectrode amperometry reveals sickle-cell-induced inflammation and chronic morphine effects on single mast cells.

Authors: Benjamin M Manning; Robert P Hebbel; Kalpna Gupta; Christy L Haynes
Journal: ACS Chem Biol Date: 2012-01-23 Impact factor: 5.100

3. GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice.

Authors: Jungshan Chang; John T Patton; Arun Sarkar; Beat Ernst; John L Magnani; Paul S Frenette
Journal: Blood Date: 2010-05-27 Impact factor: 22.113

4. Targeting Mac-1-mediated leukocyte-RBC interactions uncouples the benefits for acute vaso-occlusion and chronic organ damage.

Authors: Grace Chen; Jungshan Chang; Dachuan Zhang; Sandra Pinho; Jung-Eun Jang; Paul S Frenette
Journal: Exp Hematol Date: 2016-07-05 Impact factor: 3.084

10. Increased levels of the inflammatory biomarker C-reactive protein at baseline are associated with childhood sickle cell vasocclusive crises.

Authors: Suba Krishnan; Yamaja Setty; Suhita G Betal; Vaidyula Vijender; Koneti Rao; Carlton Dampier; Marie Stuart
Journal: Br J Haematol Date: 2009-12-08 Impact factor: 6.998