OBJECTIVE: The primary purpose of this study was to confirm the association of a specific haplotype of the dopamine transporter gene and attention deficit hyperactivity disorder (ADHD), which could be one source of the heterogeneity seen across published studies. METHOD: The authors previously reported the association of ADHD with a subgroup of chromosomes containing specific alleles of two variable-number tandem repeat polymorphisms within the 3' untranslated region and intron 8 of the dopamine transporter gene. They now report on this association in a sample of ADHD combined-type probands. RESULTS: The original observations were confirmed, with an overall odds ratio of 1.4 across samples. CONCLUSIONS: These data challenge results of meta-analyses suggesting that dopamine transporter variation does not have an effect on the risk for ADHD, and they indicate that further investigation of functional variation in the gene is required.
OBJECTIVE: The primary purpose of this study was to confirm the association of a specific haplotype of the dopamine transporter gene and attention deficit hyperactivity disorder (ADHD), which could be one source of the heterogeneity seen across published studies. METHOD: The authors previously reported the association of ADHD with a subgroup of chromosomes containing specific alleles of two variable-number tandem repeat polymorphisms within the 3' untranslated region and intron 8 of the dopamine transporter gene. They now report on this association in a sample of ADHD combined-type probands. RESULTS: The original observations were confirmed, with an overall odds ratio of 1.4 across samples. CONCLUSIONS: These data challenge results of meta-analyses suggesting that dopamine transporter variation does not have an effect on the risk for ADHD, and they indicate that further investigation of functional variation in the gene is required.
Authors: Yannis Paloyelis; Philip Asherson; Mitul A Mehta; Stephen V Faraone; Jonna Kuntsi Journal: Neuropsychopharmacology Date: 2010-08-25 Impact factor: 7.853
Authors: Yannis Paloyelis; Mitul A Mehta; Stephen V Faraone; Philip Asherson; Jonna Kuntsi Journal: J Am Acad Child Adolesc Psychiatry Date: 2012-06-05 Impact factor: 8.829
Authors: Tomasz Schneider; Nicholas Ilott; Giovana Brolese; Lisiane Bizarro; Philip J E Asherson; Ian P Stolerman Journal: Neuropsychopharmacology Date: 2011-02-02 Impact factor: 7.853
Authors: Tiffany A Greenwood; Eun-Jeong Joo; Tatyana Shekhtman; A Dessa Sadovnick; Ronald A Remick; Paul E Keck; Susan L McElroy; John R Kelsoe Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2012-12-19 Impact factor: 3.568