OBJECTIVES: Few studies have examined the characteristics and clinical course of children hospitalized with laboratory-confirmed influenza. We sought to (1) estimate the age-specific incidence of influenza-related hospitalizations, (2) describe the characteristics and clinical course of children hospitalized with influenza, and (3) identify risk factors for prolonged hospitalization. PATIENTS AND METHODS: Children < or = 21 years of age hospitalized with community-acquired laboratory-confirmed influenza at a large urban children's hospital were identified through review of laboratory records and administrative data sources. A neighborhood cohort embedded within our study population was used to estimate the incidence of community-acquired laboratory-confirmed influenza hospitalizations among children < 18 years old. Risk factors for prolonged hospitalization (> 6 days) were determined by using logistic regression. RESULTS: We identified 745 children hospitalized with community-acquired laboratory-confirmed influenza during the 4-year study period. In this urban cohort, the incidence of community-acquired laboratory-confirmed influenza hospitalization was 7 per 10,000 child-years of observation. The median age was 1.8 years; 25% were infants < 6 months old, and 77% were children < 5 years old. Many children (49%) had a medical condition associated with an increased risk of influenza-related complications. The incidence of influenza-related complications was higher among children with a preexisting high-risk condition than for previously healthy children (29% vs 21%). However, only cardiac and neurologic/neuromuscular diseases were found to be independent risk factors for prolonged hospitalization. CONCLUSIONS: Influenza is a common cause of hospitalization among both healthy and chronically ill children. Children with cardiac or neurologic/neuromuscular disease are at increased risk of prolonged hospitalization; therefore, children with these conditions and their contacts should be a high priority to receive vaccine. The impact on pediatric hospitalization of the new recommendation to vaccinate all children 6 months to < 5 years old should be assessed.
OBJECTIVES: Few studies have examined the characteristics and clinical course of children hospitalized with laboratory-confirmed influenza. We sought to (1) estimate the age-specific incidence of influenza-related hospitalizations, (2) describe the characteristics and clinical course of children hospitalized with influenza, and (3) identify risk factors for prolonged hospitalization. PATIENTS AND METHODS: Children < or = 21 years of age hospitalized with community-acquired laboratory-confirmed influenza at a large urban children's hospital were identified through review of laboratory records and administrative data sources. A neighborhood cohort embedded within our study population was used to estimate the incidence of community-acquired laboratory-confirmed influenza hospitalizations among children < 18 years old. Risk factors for prolonged hospitalization (> 6 days) were determined by using logistic regression. RESULTS: We identified 745 children hospitalized with community-acquired laboratory-confirmed influenza during the 4-year study period. In this urban cohort, the incidence of community-acquired laboratory-confirmed influenza hospitalization was 7 per 10,000 child-years of observation. The median age was 1.8 years; 25% were infants < 6 months old, and 77% were children < 5 years old. Many children (49%) had a medical condition associated with an increased risk of influenza-related complications. The incidence of influenza-related complications was higher among children with a preexisting high-risk condition than for previously healthy children (29% vs 21%). However, only cardiac and neurologic/neuromuscular diseases were found to be independent risk factors for prolonged hospitalization. CONCLUSIONS: Influenza is a common cause of hospitalization among both healthy and chronically ill children. Children with cardiac or neurologic/neuromuscular disease are at increased risk of prolonged hospitalization; therefore, children with these conditions and their contacts should be a high priority to receive vaccine. The impact on pediatric hospitalization of the new recommendation to vaccinate all children 6 months to < 5 years old should be assessed.
Authors: Deborah L Thompson; Jessica Jungk; Emily Hancock; Chad Smelser; Michael Landen; Megin Nichols; David Selvage; Joan Baumbach; Mack Sewell Journal: Am J Public Health Date: 2011-07-21 Impact factor: 9.308
Authors: Carmen S Arriola; Melissa C Mercado-Crespo; Brenda Rivera; Ruby Serrano-Rodriguez; Nora Macklin; Angel Rivera; Samuel Graitcer; Mayra Lacen; Carolyn B Bridges; Erin D Kennedy Journal: Vaccine Date: 2015-07-02 Impact factor: 3.641
Authors: Byung-Kwang Yoo; Sharon G Humiston; Peter G Szilagyi; Stanley J Schaffer; Christine Long; Maureen Kolasa Journal: BMC Health Serv Res Date: 2015-11-16 Impact factor: 2.655
Authors: Pranita D Tamma; Alison E Turnbull; Aaron M Milstone; Sara E Cosgrove; Alexandra Valsamakis; Alicia Budd; Trish M Perl Journal: BMC Pediatr Date: 2010-10-06 Impact factor: 2.125
Authors: Charisma Dilantika; Endang R Sedyaningsih; Matthew R Kasper; Magdarina Agtini; Erlin Listiyaningsih; Timothy M Uyeki; Timothy H Burgess; Patrick J Blair; Shannon D Putnam Journal: BMC Infect Dis Date: 2010-01-07 Impact factor: 3.090