Literature DB >> 17400503

Galleria mellonella as a model host to study infection by the Francisella tularensis live vaccine strain.

George Aperis1, Beth Burgwyn Fuchs, Christine A Anderson, John E Warner, Stephen B Calderwood, Eleftherios Mylonakis.   

Abstract

We used the killing of Galleria mellonella (Lepidoptera: Pyralidae; the greater wax moth) caterpillar by the live vaccine strain (LVS) of Francisella tularensis to develop an invertebrate host system that can be used to study F. tularensis infection and the in vivo effects of antibacterial compounds on F. tularensis LVS. After injection into the insect hemocoel, F. tularensis LVS, killed caterpillars despite the association of LVS with hemocytes. The rate of killing depended on the number of bacteria injected. Antibiotic therapy with ciprofloxacin, levofloxacin or streptomycin administered before or after inoculation prolonged survival and decreased the tissue burden of F. tularensis in the hemocoel. Delayed drug treatment reduced the efficacy of antibacterials and especially streptomycin. The G. mellonella-F. tularensis LVS system may facilitate the in vivo study of F. tularensis, efficacy with antibacterial agents.

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Year:  2007        PMID： 17400503      PMCID： PMC1974785          DOI： 10.1016/j.micinf.2007.02.016

Source DB:  PubMed          Journal:  Microbes Infect        ISSN： 1286-4579            Impact factor:   2.700


  22 in total

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