Literature DB >> 17400463

Synthesis and antiproliferative activity of some novel derivatives of diospyrin, a plant-derived naphthoquinonoid.

Madhushree Das Sarma1, Rina Ghosh, Amarendra Patra, Banasri Hazra.   

Abstract

Derivatisation of diospyrin, a bisnaphthoquinonoid isolated from Diospyros montana Roxb., led to the modification of its inhibitory activity, in vitro, towards a murine tumour model, Ehrlich ascites carcinoma (EAC), and two human cancer cell lines, viz., malignant skin melanoma (A375) and epidermoid laryngeal carcinoma (Hep2). Among the novel derivatives, an epoxide exhibited the maximum antiproliferative activity (IC(50) values in the range of 0.03-0.21 microM) and a comparatively lower toxicity (IC(50) approximately 98 microM) in normal human peripheral blood mononuclear cells (PBMC). This compound might provide a novel 'lead' for the development of clinically effective antiproliferative agents against cancer.

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Year:  2007        PMID： 17400463     DOI： 10.1016/j.bmc.2007.03.050

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  9 in total

1.  Acetylamine derivative of diospyrin, a plant-derived binaphthylquinonoid, inhibits human colon cancer growth in Nod-Scid mice.

Authors:  Sudipta Hazra; Subhalakshmi Ghosh; Amit Kumar; B N Pandey; Banasri Hazra
Journal:  Invest New Drugs       Date:  2014-09-30       Impact factor: 3.850

2.  Antitumor efficacy and apoptotic activity of substituted chloroalkyl 1H-benz[de]isoquinoline-1,3-diones: a new class of potential antineoplastic agents.

Authors:  Asama Mukherjee; Suva Hazra; Sushanta Dutta; Shanmugavel Muthiah; Dilip Manikrao Mondhe; Parduman Raj Sharma; Shashank Kumar Singh; Ajit Kumar Saxena; Gulam Nabi Qazi; Utpal Sanyal
Journal:  Invest New Drugs       Date:  2010-01-12       Impact factor: 3.850

3.  Radiosensitization by diospyrin diethylether in MCF-7 breast carcinoma cell line.

Authors:  Binod Kumar; Jayashree Joshi; Amit Kumar; Badri N Pandey; Banasri Hazra; Kaushala P Mishra
Journal:  Mol Cell Biochem       Date:  2007-05-30       Impact factor: 3.396

4.  Effect of metronidazole analogues on Giardia lamblia cultures.

Authors:  Haendel G N O Busatti; Andrea E D Vieira; João C Viana; Hugo E Silva; Elaine M Souza-Fagundes; Olindo A Martins-Filho; Ricardo J Alves; Maria A Gomes
Journal:  Parasitol Res       Date:  2007-09-30       Impact factor: 2.289

5.  6-Nitro-2-(3-hydroxypropyl)-1H-benz[de]isoquinoline-1,3-dione, a potent antitumor agent, induces cell cycle arrest and apoptosis.

Authors:  Asama Mukherjee; Sushanta Dutta; Muthiah Shanmugavel; Dilip M Mondhe; Parduman R Sharma; Shashank K Singh; Ajit K Saxena; Utpal Sanyal
Journal:  J Exp Clin Cancer Res       Date:  2010-12-31

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Authors:  Bharathi Raja Subramaniya; Gayathri Srinivasan; Sakeena Sadullah Mohammed Sadullah; Nimitha Davis; Lakshmi Baddi Reddi Subhadara; Devaraj Halagowder; Niranjali Devaraj Sivasitambaram
Journal:  PLoS One       Date:  2011-04-29       Impact factor: 3.240

7.  Evaluation of cytotoxic activity of platinum nanoparticles against normal and cancer cells and its anticancer potential through induction of apoptosis.

Authors:  Yogesh Bendale; Vineeta Bendale; Saili Paul
Journal:  Integr Med Res       Date:  2017-02-03

8.  Synergistic induction of apoptosis in a cell model of human leukemia K562 by nitroglycerine and valproic acid.

Authors:  Shahin Aalaei; Mehdi Mohammadzadeh; Yaghub Pazhang
Journal:  EXCLI J       Date:  2019-08-15       Impact factor: 4.068

9.  Role of mitochondrial oxidative stress in the apoptosis induced by diospyrin diethylether in human breast carcinoma (MCF-7) cells.

Authors:  Binod Kumar; Amit Kumar; B N Pandey; K P Mishra; Banasri Hazra
Journal:  Mol Cell Biochem       Date:  2008-10-04       Impact factor: 3.842
  9 in total

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