| Literature DB >> 17400453 |
Koushi Hidaka1, Tooru Kimura, Yumi Tsuchiya, Mami Kamiya, Adam J Ruben, Ernesto Freire, Yoshio Hayashi, Yoshiaki Kiso.
Abstract
Based on a highly potent allophenylnorstatine-containing inhibitor, KNI-10006, against the plasmepsins of Plasmodium falciparum, we synthesized a series of tripeptide-type compounds with various N-terminal moieties and evaluated their inhibitory activities against plasmepsin II. Certain phenylacetyl derivatives exhibited extremely high affinity with K(i) values of less than 0.1n M suggesting successful hydrophobic interactions.Entities:
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Year: 2007 PMID： 17400453 DOI： 10.1016/j.bmcl.2007.03.052
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823