| Literature DB >> 17400014 |
Ana Paula Bordon1, Luciane Alarcão Dias-Melicio, Michele Janegitz Acorci, Sueli Aparecida Calvi, Maria Terezinha Serrão Peraçoli, Angela Maria Victoriano de Campos Soares.
Abstract
Human monocytes lacked fungicidal activity against high virulence strain of Paracoccidioides brasiliensis, even after IFN-gamma activation. However, monocytes treated with indomethacin exhibited an effective killing against this fungus, suggesting a role of prostaglandin E2 (PGE2) in the inhibition process. Thus, the purpose of this work was to determine whether the effect of PGE2 in fungicidal activity was related with decrease on H(2)O(2) release, the metabolite involved in P. brasiliensis killing, and changes in the levels of TNF-alpha, IL-6 and IL-10. Human monocytes challenged with the fungus produced high PGE2 levels, which in turn inhibited the fungicidal activity of these cells by reducing H(2)O(2) and TNF-alpha production.Entities:
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Year: 2007 PMID： 17400014 DOI： 10.1016/j.micinf.2007.02.019
Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700